Mohammad Taghi Mansouri1, Bahareh Naghizadeh2, Behnam Ghorbanzadeh3. 1. Department of Pharmacology, School of Medicine, Physiology and Atherosclerosis Research Centers, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran. Electronic address: mansouri_smt@yahoo.com. 2. Department of Pharmacology, School of Medicine, Pain and Physiology Research Centers, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran. 3. Department of Pharmacology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences (AJUMS), Ahvaz, Iran.
Abstract
BACKGROUND: Several antidepressants have been used to treat severe pain in clinics. Recently, it has been shown that ellagic acid (EA), a major constituent of pomegranate juice, produced antinociceptive and anti-inflammatory effect through the central and peripheral sites of action. MATERIALS AND METHODS: In this study, we examined the interaction between EA and venlafaxine (VLF) on pain induced by intraperitoneal acetic acid in mice using isobolographic analysis. RESULTS: EA (0.3-10mg/kg, ip) and VLF (3-60 mg/kg, ip) produced a dose-dependent inhibition of the writhing response evoked by acetic acid. Fifty percent effective dose (ED50) values against writhing behaviors were 1.02 (0.86-1.19)mg/kg and 12.37 (9.74-15.37)mg/kg for EA and VLF, respectively, and also with higher potency than that of VLF. Co-administration of increasing fractional increments of ED50 doses of EA and VLF produced synergistic interaction against writhing behaviors, as revealed by isobolographic analysis. CONCLUSION: The synergistic action of EA and VLF provides valuable tool referring to the management of visceral pain.
BACKGROUND: Several antidepressants have been used to treat severe pain in clinics. Recently, it has been shown that ellagic acid (EA), a major constituent of pomegranate juice, produced antinociceptive and anti-inflammatory effect through the central and peripheral sites of action. MATERIALS AND METHODS: In this study, we examined the interaction between EA and venlafaxine (VLF) on pain induced by intraperitoneal acetic acid in mice using isobolographic analysis. RESULTS:EA (0.3-10mg/kg, ip) and VLF (3-60 mg/kg, ip) produced a dose-dependent inhibition of the writhing response evoked by acetic acid. Fifty percent effective dose (ED50) values against writhing behaviors were 1.02 (0.86-1.19)mg/kg and 12.37 (9.74-15.37)mg/kg for EA and VLF, respectively, and also with higher potency than that of VLF. Co-administration of increasing fractional increments of ED50 doses of EA and VLF produced synergistic interaction against writhing behaviors, as revealed by isobolographic analysis. CONCLUSION: The synergistic action of EA and VLF provides valuable tool referring to the management of visceral pain.
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