Adnan A Hismiogullari1, Sahver E Hismiogullari2, Omur Karaca3, Fatma B Sunay4, Serpil Paksoy5, Mehmet Can6, Iter Kus3, Kamil Seyrek7, Ozlem Yavuz7. 1. Department of Medical Biochemistry, School of Medicine, Balikesir University, Balikesir, Turkey. Electronic address: ahismiogullari@gmail.com. 2. Department of Pharmacology and Toxicology, School of Veterinary Medicine, Balkesir University, Balikesir, Turkey. 3. Department of Anatomy, School of Medicine, Balikesir University, Balikesir, Turkey. 4. Department of Histology and Embryology, School of Medicine, Balikesir University, Balikesir, Turkey. 5. Department of Pathology, School of Medicine, Balikesir University, Balikesir, Turkey. 6. Department of Anatomy, School of Veterinary Medicine, Balikesir University, Balikesir, Turkey. 7. Department of Medical Biochemistry, School of Medicine, Balikesir University, Balikesir, Turkey.
Abstract
BACKGROUND: The aim of the present study was to examine the protective effect of curcumin (CUR) on carbon tetrachloride (CCl4)-induced nephrotoxicity to evaluate the detailed mechanisms by which CUR exerts its protective action. METHODS: Thirty male Wistar-Albino rats weighing 250-300 g were randomly divided into three groups: administrations of olive oil (control, po), CCl4 (0.5mg/kg in olive oil sc) every other day for 3 weeks, and CCl4 (0.5mg/kg in olive oil sc) plus CUR (200mg/kg) every day for 3 weeks. RESULTS: Administration of CCl4 significantly (p<0.001) increased the levels of renal function test such as creatinine and blood urea nitrogen (BUN). Furthermore, treatment of CCl4 significantly elevated the oxidant status of renal tissues while decreasing its anti-oxidant status (p<0.001). CUR displayed a renal protective effect as evident by significant decrease in inflammation and apoptosis during histopathological examination. The administration of CCl4 resulted in an increase in malondialdehyde (MDA) production due to an increase in membrane lipid peroxidation; however, the administration of CUR attenuated this, probably via its antioxidant and free radical scavenging properties. CONCLUSION: The finding of our study indicates that CUR may have an important role to play in protecting the kidney from oxidative insult.
BACKGROUND: The aim of the present study was to examine the protective effect of curcumin (CUR) on carbon tetrachloride (CCl4)-induced nephrotoxicity to evaluate the detailed mechanisms by which CUR exerts its protective action. METHODS: Thirty male Wistar-Albino rats weighing 250-300 g were randomly divided into three groups: administrations of olive oil (control, po), CCl4 (0.5mg/kg in olive oil sc) every other day for 3 weeks, and CCl4 (0.5mg/kg in olive oil sc) plus CUR (200mg/kg) every day for 3 weeks. RESULTS: Administration of CCl4 significantly (p<0.001) increased the levels of renal function test such as creatinine and blood ureanitrogen (BUN). Furthermore, treatment of CCl4 significantly elevated the oxidant status of renal tissues while decreasing its anti-oxidant status (p<0.001). CUR displayed a renal protective effect as evident by significant decrease in inflammation and apoptosis during histopathological examination. The administration of CCl4 resulted in an increase in malondialdehyde (MDA) production due to an increase in membrane lipid peroxidation; however, the administration of CUR attenuated this, probably via its antioxidant and free radical scavenging properties. CONCLUSION: The finding of our study indicates that CUR may have an important role to play in protecting the kidney from oxidative insult.
Authors: Babatunji Emmanuel Oyinloye; Foluso Oluwagbemiga Osunsanmi; Basiru Olaitan Ajiboye; Oluwafemi Adeleke Ojo; Abidemi Paul Kappo Journal: Int J Environ Res Public Health Date: 2017-08-24 Impact factor: 3.390
Authors: Mariama Salihu; Gaber El-Saber Batiha; Keneth Iceland Kasozi; George D Zouganelis; Souty M Z Sharkawi; Eman Ibrahim Ahmed; Ibe Michael Usman; Halima Nalugo; Juma J Ochieng; Ibrahim Ssengendo; Olatayo Segun Okeniran; Theophilus Pius; Kyobe Ronald Kimanje; Eric Simidi Kegoye; Ritah Kenganzi; Fred Ssempijja Journal: Toxicol Rep Date: 2022-03-29