Literature DB >> 25933820

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.

Takamitsu Saigusa1, P Darwin Bell2.   

Abstract

Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future clinical studies. ©2015 Int. Union Physiol. Sci./Am. Physiol. Soc.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25933820      PMCID： PMC4422974          DOI： 10.1152/physiol.00032.2014

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  158 in total

1.  G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease.

Authors:  Michelle Kwon; Tengis S Pavlov; Kandai Nozu; Shauna A Rasmussen; Daria V Ilatovskaya; Alexandra Lerch-Gaggl; Lauren M North; Hyunho Kim; Feng Qian; William E Sweeney; Ellis D Avner; Joe B Blumer; Alexander Staruschenko; Frank Park
Journal:  Proc Natl Acad Sci U S A       Date:  2012-12-10       Impact factor: 11.205

2.  TRPV4 dysfunction promotes renal cystogenesis in autosomal recessive polycystic kidney disease.

Authors:  Oleg Zaika; Mykola Mamenko; Jonathan Berrout; Nabila Boukelmoune; Roger G O'Neil; Oleh Pochynyuk
Journal:  J Am Soc Nephrol       Date:  2013-02-14       Impact factor: 10.121

3.  Factors affecting the progression of renal disease in autosomal-dominant polycystic kidney disease.

Authors:  P A Gabow; A M Johnson; W D Kaehny; W J Kimberling; D C Lezotte; I T Duley; R H Jones
Journal:  Kidney Int       Date:  1992-05       Impact factor: 10.612

4.  mTOR inhibition in autosomal-dominant polycystic kidney disease (ADPKD): the question remains open.

Authors:  Meg J Jardine; Thaminda Liyanage; Erin Buxton; Vlado Perkovic
Journal:  Nephrol Dial Transplant       Date:  2012-12-05       Impact factor: 5.992

5.  Functional polycystin-1 dosage governs autosomal dominant polycystic kidney disease severity.

Authors:  Katharina Hopp; Christopher J Ward; Cynthia J Hommerding; Samih H Nasr; Han-Fang Tuan; Vladimir G Gainullin; Sandro Rossetti; Vicente E Torres; Peter C Harris
Journal:  J Clin Invest       Date:  2012-10-15       Impact factor: 14.808

6.  Tolvaptan in patients with autosomal dominant polycystic kidney disease.

Authors:  Vicente E Torres; Arlene B Chapman; Olivier Devuyst; Ron T Gansevoort; Jared J Grantham; Eiji Higashihara; Ronald D Perrone; Holly B Krasa; John Ouyang; Frank S Czerwiec
Journal:  N Engl J Med       Date:  2012-11-03       Impact factor: 91.245

7.  Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases.

Authors:  Tatyana V Masyuk; Brynn N Radtke; Angela J Stroope; Jesús M Banales; Sergio A Gradilone; Bing Huang; Anatoliy I Masyuk; Marie C Hogan; Vicente E Torres; Nicholas F Larusso
Journal:  Hepatology       Date:  2013-03-06       Impact factor: 17.425

8.  High incidence of rejection episodes and poor tolerance of sirolimus in a protocol with early steroid withdrawal and calcineurin inhibitor-free maintenance therapy in renal transplantation: experiences of a randomized prospective single-center study.

Authors:  F Burkhalter; T Oettl; B Descoeudres; A Bachmann; L Guerke; M J Mihatsch; M Dickenmann; J Steiger
Journal:  Transplant Proc       Date:  2012-12       Impact factor: 1.066

9.  miR-17~92 miRNA cluster promotes kidney cyst growth in polycystic kidney disease.

Authors:  Vishal Patel; Darren Williams; Sachin Hajarnis; Ryan Hunter; Marco Pontoglio; Stefan Somlo; Peter Igarashi
Journal:  Proc Natl Acad Sci U S A       Date:  2013-06-12       Impact factor: 11.205

10.  Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy.

Authors:  Isaline Rowe; Marco Chiaravalli; Valeria Mannella; Valeria Ulisse; Giacomo Quilici; Monika Pema; Xuewen W Song; Hangxue Xu; Silvia Mari; Feng Qian; York Pei; Giovanna Musco; Alessandra Boletta
Journal:  Nat Med       Date:  2013-03-24       Impact factor: 53.440
View more
  22 in total

1.  Reciprocal effect of angiotensin II in collecting duct renin synthesis.

Authors:  Takamitsu Saigusa
Journal:  Am J Physiol Renal Physiol       Date:  2015-09-16

2.  Understanding renal physiology leads to therapeutic advances in renal disease.

Authors:  Jeff M Sands
Journal:  Physiology (Bethesda)       Date:  2015-05

3.  Effect of a Vasopressin V2 Receptor Antagonist on Polycystic Kidney Disease Development in a Rat Model.

Authors:  Xiaofang Wang; Megan M Constans; Fouad T Chebib; Vicente E Torres; Lorenzo Pellegrini
Journal:  Am J Nephrol       Date:  2019-05-22       Impact factor: 3.754

4.  Suppressing angiotensinogen synthesis attenuates kidney cyst formation in a Pkd1 mouse model.

Authors:  Takamitsu Saigusa; Yujing Dang; Adam E Mullick; Steve T Yeh; Michael R Zile; Catalin F Baicu; P Darwin Bell
Journal:  FASEB J       Date:  2015-09-21       Impact factor: 5.191

5.  Interleukin-1 receptor activation aggravates autosomal dominant polycystic kidney disease by modulating regulated necrosis.

Authors:  Bo Yang; Lili Fu; Jamie R Privratsky; Xiaohan Lu; Jiafa Ren; Changlin Mei; Steven D Crowley
Journal:  Am J Physiol Renal Physiol       Date:  2019-05-29

6.  Casein kinase 1ε and 1α as novel players in polycystic kidney disease and mechanistic targets for (R)-roscovitine and (S)-CR8.

Authors:  Katy Billot; Charlène Coquil; Benoit Villiers; Béatrice Josselin-Foll; Nathalie Desban; Claire Delehouzé; Nassima Oumata; Yannick Le Meur; Alessandra Boletta; Thomas Weimbs; Melanie Grosch; Ralph Witzgall; Sophie Saunier; Evelyne Fischer; Marco Pontoglio; Alain Fautrel; Michal Mrug; Darren Wallace; Pamela V Tran; Marie Trudel; Nikolay Bukanov; Oxana Ibraghimov-Beskrovnaya; Laurent Meijer
Journal:  Am J Physiol Renal Physiol       Date:  2018-03-14

7.  The native TRPP2-dependent channel of murine renal primary cilia.

Authors:  Steven J Kleene; Nancy K Kleene
Journal:  Am J Physiol Renal Physiol       Date:  2016-10-19

Review 8.  Polycystin and calcium signaling in cell death and survival.

Authors:  Fernanda O Lemos; Barbara E Ehrlich
Journal:  Cell Calcium       Date:  2017-05-24       Impact factor: 6.817

9.  Attenuation of accelerated renal cystogenesis in Pkd1 mice by renin-angiotensin system blockade.

Authors:  Wayne R Fitzgibbon; Yujing Dang; Marlene A Bunni; Catalin F Baicu; Michael R Zile; Adam E Mullick; Takamitsu Saigusa
Journal:  Am J Physiol Renal Physiol       Date:  2017-10-11

10.  Transdermal Delivery of Kidney-Targeting Nanoparticles Using Dissolvable Microneedles.

Authors:  Nirmalya Tripathy; Jonathan Wang; Madelynn Tung; Claire Conway; Eun Ji Chung
Journal:  Cell Mol Bioeng       Date:  2020-06-01       Impact factor: 2.321
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.