AIMS: Scientific evidence on the effects of chronic periodontitis on end-stage renal disease (ESRD) remains inadequate and inconclusive. This intervention study was designed to evaluate the effects of non-surgical periodontal therapy on the clinical response and systemic status of ESRD patients. MATERIALS AND METHODS: Patients in the intervention group (n = 48) received non-surgical periodontal therapy and then a supragingival prophylaxis at the 3-month follow up, and those in the control group (n = 49) received no intervention throughout the study. At 6 weeks, 3 months, and 6 months after therapy, clinical periodontal examinations were conducted and blood samples were taken to evaluate inflammatory, nutritional and lipid profiles. RESULTS: The results showed a significant improvement in clinical periodontal parameters (p < 0.05) in the intervention group. Compared to the control group, the intervention group had significantly lower high-sensitivity C-reactive protein at 3 months and 6 months. Significant improvements were found (p < 0.05) in interleukin-6, ferritin, albumin, creatinine, blood urea nitrogen, and transferrin after therapy. CONCLUSIONS:Non-surgical periodontal therapy can effectively improve periodontal, circulating inflammatory and nutritional status in ESRD patients. Non-surgical periodontal therapy, as a relatively simple intervention, has beneficial systemic effects in ESRD patients.
RCT Entities:
AIMS: Scientific evidence on the effects of chronic periodontitis on end-stage renal disease (ESRD) remains inadequate and inconclusive. This intervention study was designed to evaluate the effects of non-surgical periodontal therapy on the clinical response and systemic status of ESRDpatients. MATERIALS AND METHODS:Patients in the intervention group (n = 48) received non-surgical periodontal therapy and then a supragingival prophylaxis at the 3-month follow up, and those in the control group (n = 49) received no intervention throughout the study. At 6 weeks, 3 months, and 6 months after therapy, clinical periodontal examinations were conducted and blood samples were taken to evaluate inflammatory, nutritional and lipid profiles. RESULTS: The results showed a significant improvement in clinical periodontal parameters (p < 0.05) in the intervention group. Compared to the control group, the intervention group had significantly lower high-sensitivity C-reactive protein at 3 months and 6 months. Significant improvements were found (p < 0.05) in interleukin-6, ferritin, albumin, creatinine, blood ureanitrogen, and transferrin after therapy. CONCLUSIONS: Non-surgical periodontal therapy can effectively improve periodontal, circulating inflammatory and nutritional status in ESRDpatients. Non-surgical periodontal therapy, as a relatively simple intervention, has beneficial systemic effects in ESRDpatients.
Authors: Dan Zhao; Abrar Tahir Khawaja; Lijian Jin; Kam Wa Chan; Maurizio Tonetti; Sydney Chi Wai Tang; George Pelekos Journal: Clin Oral Investig Date: 2019-11-12 Impact factor: 3.573
Authors: Fabienne A Gerber; Philipp Sahrmann; Oliver A Schmidlin; Christian Heumann; Jürg Hans Beer; Patrick R Schmidlin Journal: BMC Oral Health Date: 2016-09-02 Impact factor: 2.757
Authors: Quan Yuan; Qiu-Chan Xiong; Megha Gupta; Rosa María López-Pintor; Xiao-Lei Chen; Dutmanee Seriwatanachai; Michael Densmore; Yi Man; Ping Gong Journal: Int J Oral Sci Date: 2017-06-23 Impact factor: 6.344
Authors: Praveen Sharma; Thomas Dietrich; Charles J Ferro; Paul Cockwell; Iain L C Chapple Journal: J Clin Periodontol Date: 2016-02-18 Impact factor: 8.728