| Literature DB >> 25932618 |
Miguel A Barbancho1, Marcelo L Berthier2, Patricia Navas-Sánchez1, Guadalupe Dávila2, Cristina Green-Heredia3, José M García-Alberca4, Rafael Ruiz-Cruces1, Manuel V López-González1, Marc S Dawid-Milner1, Friedemann Pulvermüller5, J Pablo Lara6.
Abstract
Changes in ERP (P100 and N400) and root mean square (RMS) were obtained during a silent reading task in 28 patients with chronic post-stroke aphasia in a randomized, double-blind, placebo-controlled trial of both memantine and constraint-induced aphasia therapy (CIAT). Participants received memantine/placebo alone (weeks 0-16), followed by drug treatment combined with CIAT (weeks 16-18), and then memantine/placebo alone (weeks 18-20). ERP/RMS values (week 16) decreased more in the memantine group than in the placebo group. During CIAT application (weeks 16-18), improvements in aphasia severity and ERP/RMS values were amplified by memantine and changes remained stable thereafter (weeks 18-20). Changes in ERP/RMS occurred in left and right hemispheres and correlated with gains in language performance. No changes in ERP/RMS were found in a healthy group in two separated evaluations. Our results show that aphasia recovery induced by both memantine alone and in combination with CIAT is indexed by bilateral cortical potentials.Entities:
Keywords: Aphasia recovery; Constraint-induced aphasia therapy; Event-related potentials; Memantine; Stroke
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Year: 2015 PMID： 25932618 DOI： 10.1016/j.bandl.2015.04.003
Source DB: PubMed Journal: Brain Lang ISSN： 0093-934X Impact factor: 2.381