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Literature DB >> 25932301

Deep brain stimulation of the subthalamic and pedunculopontine nucleus in a patient with Parkinson's disease.

Huan-Guang Liu¹, Kai Zhang¹, An-Chao Yang¹, Jian-Guo Zhang².

Abstract

Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel therapy developed to treat Parkinson's disease. We report a patient who underwent bilateral DBS of the PPN and subthalamic nucleus (STN). He suffered from freezing of gait (FOG), bradykinesia, rigidity and mild tremors. The patient underwent bilateral DBS of the PPN and STN. We compared the benefits of PPN-DBS and STN-DBS using motor and gait subscores. The PPN-DBS provided modest improvements in the gait disorder and freezing episodes, while the STN-DBS failed to improve the dominant problems. This special case suggests that PPN-DBS may have a unique role in ameliorating the locomotor symptoms and has the potential to provide improvement in FOG.

Entities: CellLine Chemical Disease Gene Species

Keywords: Deep brain stimulation; Parkinson's disease; Pedunculopontine nucleus; Subthalamic nucleus

Year: 2015 PMID： 25932301 PMCID： PMC4414778 DOI： 10.3340/jkns.2015.57.4.303

Source DB: PubMed Journal: J Korean Neurosurg Soc ISSN： 1225-8245

26 in total

1. What does the pedunculopontine nucleus do?

Authors: Joseph Classen; Alfons Schnitzler
Journal: Neurology Date: 2010-08-11 Impact factor: 9.910

2. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.

Authors: Alessandro Stefani; Andres M Lozano; Antonella Peppe; Paolo Stanzione; Salvatore Galati; Domenicantonio Tropepi; Mariangela Pierantozzi; Livia Brusa; Eugenio Scarnati; Paolo Mazzone
Journal: Brain Date: 2007-01-24 Impact factor: 13.501

3. Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.

Authors: M C Rodriguez-Oroz; J A Obeso; A E Lang; J-L Houeto; P Pollak; S Rehncrona; J Kulisevsky; A Albanese; J Volkmann; M I Hariz; N P Quinn; J D Speelman; J Guridi; I Zamarbide; A Gironell; J Molet; B Pascual-Sedano; B Pidoux; A M Bonnet; Y Agid; J Xie; A-L Benabid; A M Lozano; J Saint-Cyr; L Romito; M F Contarino; M Scerrati; V Fraix; N Van Blercom
Journal: Brain Date: 2005-06-23 Impact factor: 13.501

4. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.

Authors: Kenneth A Follett; Frances M Weaver; Matthew Stern; Kwan Hur; Crystal L Harris; Ping Luo; William J Marks; Johannes Rothlind; Oren Sagher; Claudia Moy; Rajesh Pahwa; Kim Burchiel; Penelope Hogarth; Eugene C Lai; John E Duda; Kathryn Holloway; Ali Samii; Stacy Horn; Jeff M Bronstein; Gatana Stoner; Philip A Starr; Richard Simpson; Gordon Baltuch; Antonio De Salles; Grant D Huang; Domenic J Reda
Journal: N Engl J Med Date: 2010-06-03 Impact factor: 91.245

5. Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey.

Authors: Ned Jenkinson; Dipankar Nandi; R Chris Miall; John F Stein; Tipu Z Aziz
Journal: Neuroreport Date: 2004-12-03 Impact factor: 1.837

6. Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease.

Authors: M U Ferraye; B Debû; V Fraix; L Goetz; C Ardouin; J Yelnik; C Henry-Lagrange; E Seigneuret; B Piallat; P Krack; J-F Le Bas; A-L Benabid; S Chabardès; P Pollak
Journal: Brain Date: 2009-09-22 Impact factor: 13.501

7. Locomotion-inducing sites in the vicinity of the pedunculopontine nucleus.

Authors: E Garcia-Rill; C R Houser; R D Skinner; W Smith; D J Woodward
Journal: Brain Res Bull Date: 1987-06 Impact factor: 4.077

8. Determinants of disability and quality of life in mild to moderate Parkinson disease.

Authors: D Muslimovic; B Post; J D Speelman; B Schmand; R J de Haan
Journal: Neurology Date: 2008-06-03 Impact factor: 9.910

9. Validation of the freezing of gait questionnaire in patients with Parkinson's disease.

Authors: Nir Giladi; Joseph Tal; Tali Azulay; Oliver Rascol; David J Brooks; Eldad Melamed; Wolfgang Oertel; Werner H Poewe; Fabrizio Stocchi; Eduardo Tolosa
Journal: Mov Disord Date: 2009-04-15 Impact factor: 10.338

10. Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization.

Authors: Ludvic Zrinzo; Laurence V Zrinzo; Stephen Tisch; Patricia Dowsey Limousin; Tarek A Yousry; Farhad Afshar; Marwan I Hariz
Journal: Brain Date: 2008-05-08 Impact factor: 13.501

7 in total

Deep brain stimulation of the subthalamic and pedunculopontine nucleus in a patient with Parkinson's disease.

1. What does the pedunculopontine nucleus do?

2. Bilateral deep brain stimulation of the pedunculopontine and subthalamic nuclei in severe Parkinson's disease.

3. Bilateral deep brain stimulation in Parkinson's disease: a multicentre study with 4 years follow-up.

4. Pallidal versus subthalamic deep-brain stimulation for Parkinson's disease.

5. Pedunculopontine nucleus stimulation improves akinesia in a Parkinsonian monkey.

6. Effects of pedunculopontine nucleus area stimulation on gait disorders in Parkinson's disease.

7. Locomotion-inducing sites in the vicinity of the pedunculopontine nucleus.

8. Determinants of disability and quality of life in mild to moderate Parkinson disease.

9. Validation of the freezing of gait questionnaire in patients with Parkinson's disease.

10. Stereotactic localization of the human pedunculopontine nucleus: atlas-based coordinates and validation of a magnetic resonance imaging protocol for direct localization.

1. Neuroprotective effect of matrine on MPTP-induced Parkinson's disease and on Nrf2 expression.

Review 2. The Invention and Early History of the N-Localizer for Stereotactic Neurosurgery.

Review 3. Rescue Procedures after Suboptimal Deep Brain Stimulation Outcomes in Common Movement Disorders.

Review 4. Dopamine and the Brainstem Locomotor Networks: From Lamprey to Human.

5. Protective Effect of Puerarin Against Oxidative Stress Injury of Neural Cells and Related Mechanisms.

Review 6. Parkinson's disease as a system-level disorder.

7. Vitexin protects dopaminergic neurons in MPTP-induced Parkinson's disease through PI3K/Akt signaling pathway.