Fang Xie1, Tingting Xie2, Qi Song3, Shan Xia1, Hengjin Li4. 1. Department of Dermatology, Chinese PLA General Hospital Beijing 100853 ; Medical College of PLA Beijing 100853, P. R. China. 2. Department of Pharmaceutical Care, Chinese PLA General Hospital Beijing 100853. 3. Department of Oncology, Chinese PLA General Hospital Beijing 100853. 4. Department of Dermatology, Chinese PLA General Hospital Beijing 100853.
Abstract
BACKGROUND: Epidemiological studies evaluating the association between sunscreens use and malignant melanoma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of sunscreens use with the risk of malignant melanoma. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Twenty-one studies including 7150 malignant melanoma cases about sunscreens use with the risk of malignant melanoma were included in this meta-analysis. The combined relative risk (RR) of malignant melanoma associated with sunscreens use was 1.145 (95% CI=0.912-1.438). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found. CONCLUSIONS: Our analysis indicated that sunscreens use is not associated with the risk of malignant melanoma.
BACKGROUND: Epidemiological studies evaluating the association between sunscreens use and malignant melanoma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of sunscreens use with the risk of malignant melanoma. METHODS: Pertinent studies were identified by a search in PubMed and Web of Knowledge up to October 2014. Random-effect model was used to combine the results. Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Twenty-one studies including 7150 malignant melanoma cases about sunscreens use with the risk of malignant melanoma were included in this meta-analysis. The combined relative risk (RR) of malignant melanoma associated with sunscreens use was 1.145 (95% CI=0.912-1.438). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found. CONCLUSIONS: Our analysis indicated that sunscreens use is not associated with the risk of malignant melanoma.
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