Ping Liu1, Zibai Wei2, Xiaofeng He3, Junyan Yu2, Xiangyang Tian2, Jianlan Chang2. 1. Department of Oncology, Xiangya Hospital, Central South University Changsha 410008, China ; Department of Oncology, Peace Hospital of Changzhi Medical College Changzhi 046000, China. 2. Department of Oncology, Peace Hospital of Changzhi Medical College Changzhi 046000, China. 3. Department of Research, Peace Hospital of Changzhi Medical College Changzhi 046000, China.
Abstract
BACKGROUND: CD95 rs2234767 polymorphism in the promotor region of CD95 gene has been implicated in several studies of cervical cancer. However, the results have not been conclusively established. OBJECTIVE: The main aim of this study was to deal with the controversy with respect to the correlation between CD95 rs2234767 polymorphism and risk of cervical cancer through a meta-analysis. METHODS: Association studies that pertain to CD95 rs2234767 polymorphism and risk of cervical cancer were identified up to May 26, 2014. ORs and 95% CIs were calculated assuming AA versus GG, AA + AG versus GG, AA versus AG + GG, A versus G and AG versus GG genetic models. RESULTS: A total of 5 case-control studies were included in this meta-analysis. Overall, no significant effect modification of cervical cancer risk was revealed either at the genotypic or the allelic level for CD95 rs2234767 polymorphism. This null association persisted in the stratified analysis of Asian population. CONCLUSIONS: These findings revealed that CD95 rs2234767 polymorphism may not act as a causative agent of cervical cancer. Further evidence is needed to confirm our findings.
BACKGROUND:CD95rs2234767 polymorphism in the promotor region of CD95 gene has been implicated in several studies of cervical cancer. However, the results have not been conclusively established. OBJECTIVE: The main aim of this study was to deal with the controversy with respect to the correlation between CD95rs2234767 polymorphism and risk of cervical cancer through a meta-analysis. METHODS: Association studies that pertain to CD95rs2234767 polymorphism and risk of cervical cancer were identified up to May 26, 2014. ORs and 95% CIs were calculated assuming AA versus GG, AA + AG versus GG, AA versus AG + GG, A versus G and AG versus GG genetic models. RESULTS: A total of 5 case-control studies were included in this meta-analysis. Overall, no significant effect modification of cervical cancer risk was revealed either at the genotypic or the allelic level for CD95rs2234767 polymorphism. This null association persisted in the stratified analysis of Asian population. CONCLUSIONS: These findings revealed that CD95rs2234767 polymorphism may not act as a causative agent of cervical cancer. Further evidence is needed to confirm our findings.
Authors: S H Lee; M S Shin; W S Park; S Y Kim; S M Dong; J H Pi; H K Lee; H S Kim; J J Jang; C S Kim; S H Kim; J Y Lee; N J Yoo Journal: Cancer Res Date: 1999-07-01 Impact factor: 12.701
Authors: Kathryn Sibley; Sara Rollinson; James M Allan; Alexandra G Smith; Graham R Law; Philippa L Roddam; Christine F Skibola; Martyn T Smith; Gareth J Morgan Journal: Cancer Res Date: 2003-08-01 Impact factor: 12.701
Authors: Juozas Kupcinskas; Thomas Wex; Jan Bornschein; Michael Selgrad; Marcis Leja; Elona Juozaityte; Gediminas Kiudelis; Laimas Jonaitis; Peter Malfertheiner Journal: BMC Med Genet Date: 2011-08-24 Impact factor: 2.103