Tao Xia1, Xin Liu2, Chang Jiang Du3, Xin Jin4, Xiang Qian Kong4, Gang Li5. 1. Department of Cardiac Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China ; Department of Cardiovascular Surgery, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China. 2. Department of Ultrasound Branch, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China. 3. Department of Cardiovascular Surgery, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China. 4. Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China. 5. Department of Cardiovascular Surgery, The Central Hospital of Tai'an 29 Long Tan Road, Tai'an 271000, China ; Department of Vascular Surgery, Shandong Provincial Hospital Affiliated to Shandong University 324 Jing Wu Wei Qi Road, Jinan 250021, China.
Abstract
OBJECTIVE: Several published literatures investigated the relation between a polymorphism (Leul25Val) in platelet endothelial cell adhesion molecule-1 (PECAM-1) gene and risk of coronary heart disease (CHD) and did not reach the same conclusion. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the PECAM-1 genetic polymorphism (Leul25Val) to the risk of CHD. METHODS: We identified literatures by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure databases (CNKI) and Wanfang database in China. Data from eligible studies were extracted for meta-analysis. CHD risk associated with PECAM-1 genetic polymorphism (Leul25Val) was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). The software Review Manager (Version 5.2) was used for meta-analysis. Publication bias was tested by funnel plot. RESULTS: A total of 15 studies comprising 3696 cases and 3940 controls fulfilled the inclusion criteria. Our results did not show that Leul25Val polymorphism in PECAM-1 gene was associated with the risk of CHD [(LL+LV) vs VV, OR = 1.15, 95% CI: 0.84-1.56, P = 0.38; (VV+LV) vs LL, OR = 0.96, 95% CI: 0.79-1.17, P = 0.69; V vs L, OR = 1.08, 95% CI: 0.92-1.27, P = 0.80, respectively] by a meta-analysis. CONCLUSION: The results of our meta-analysis suggested that Leul25Val polymorphism in PECAM-1 gene is not a susceptibility marker of CHD.
OBJECTIVE: Several published literatures investigated the relation between a polymorphism (Leul25Val) in platelet endothelial cell adhesion molecule-1 (PECAM-1) gene and risk of coronary heart disease (CHD) and did not reach the same conclusion. To shed light on these inconclusive findings, we performed a meta-analysis of studies relating the PECAM-1 genetic polymorphism (Leul25Val) to the risk of CHD. METHODS: We identified literatures by searching PubMed, EMBASE, Chinese National Knowledge Infrastructure databases (CNKI) and Wanfang database in China. Data from eligible studies were extracted for meta-analysis. CHD risk associated with PECAM-1 genetic polymorphism (Leul25Val) was estimated by pooled odds ratios (ORs) and 95% confidence intervals (95% CIs). The software Review Manager (Version 5.2) was used for meta-analysis. Publication bias was tested by funnel plot. RESULTS: A total of 15 studies comprising 3696 cases and 3940 controls fulfilled the inclusion criteria. Our results did not show that Leul25Val polymorphism in PECAM-1 gene was associated with the risk of CHD [(LL+LV) vs VV, OR = 1.15, 95% CI: 0.84-1.56, P = 0.38; (VV+LV) vs LL, OR = 0.96, 95% CI: 0.79-1.17, P = 0.69; V vs L, OR = 1.08, 95% CI: 0.92-1.27, P = 0.80, respectively] by a meta-analysis. CONCLUSION: The results of our meta-analysis suggested that Leul25Val polymorphism in PECAM-1 gene is not a susceptibility marker of CHD.
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