Otto A Sanchez1, Daniel A Duprez2, Lori B Daniels3, Alan S Maisel4, James D Otvos5, Carmen A Peralta6, João A Lima7, Hossein Bahrami8, David R Jacobs9. 1. School of Public Health, Division of Epidemiology & Community Health, University of Minnesota. Electronic address: sanc0050@umn.edu. 2. Division of Cardiology, University of Minnesota. 3. Division of Cardiology, University of California, San Diego. 4. School of Medicine, University of California, San Diego; and Veterans Affairs San Diego Healthcare System. 5. LipoScience. Inc. Raleigh, North Carolina. 6. School of Medicine, University of California San Francisco. 7. Division of Cardiology, Johns Hopkins Bayview Medical Center. 8. MPH Stanford Cardiology Division, Stanford School of Medicine. 9. School of Public Health, Division of Epidemiology & Community Health, University of Minnesota.
Abstract
BACKGROUND: The association between N-terminal pro B-type natriuretic peptide (NT-proBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values. METHODS: Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations. RESULTS: NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL). CONCLUSION: These results suggest the presence of two distinct biological mechanisms above and below the knot determining the association between NT-proBNP and lipoprotein particle concentrations.
BACKGROUND: The association between N-terminal pro B-type natriuretic peptide (NT-proBNP) and blood levels of small and large LDL- and HDL- particle (P) concentration may not be linear throughout the whole range of NT-proBNP values. METHODS: Linear spline regression analysis between NT-proBNP and lipoprotein particle concentrations was performed cross-sectionally in 5597 individuals from the Multi-Ethnic Study of Atherosclerosis adjusted for age, race, sex, body mass index, % of energy from saturated fats, intentional exercise, statin use, antihypertensive medication use, diabetes, IL-6 and estimated glomerular filtration rate. Spline knots were selected as the point at which the linear slope changed in these associations. RESULTS: NT-proBNP was positively associated with large LDL-P and HDL-P, but inversely associated with small LDL-P and HDL-P, but only for NT-proBNP values below the knot (range: 100-200 pg/mL). CONCLUSION: These results suggest the presence of two distinct biological mechanisms above and below the knot determining the association between NT-proBNP and lipoprotein particle concentrations.
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