Literature DB >> 25930709

Cushing's disease: towards precision medicine.

Ursula B Kaiser1.   

Abstract

The pathogenesis of Cushing's disease is poorly understood; two recent reports identifying somatic mutations in USP8 in pituitary corticotroph tumors provide exciting advances in this field. These mutations alter EGFR trafficking and signaling, raising the prospect that EGFR inhibitors may move the treatment of this disease into the era of precision medicine.

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Year:  2015        PMID： 25930709      PMCID： PMC4456621          DOI： 10.1038/cr.2015.53

Source DB:  PubMed          Journal:  Cell Res        ISSN： 1001-0602            Impact factor:   25.617


  6 in total

Review 1.  Degradation of ubiquitin: the fate of the cellular reaper.

Authors:  Nitzan Shabek; Aaron Ciechanover
Journal:  Cell Cycle       Date:  2010-02-01       Impact factor: 4.534

2.  Mutations in the deubiquitinase gene USP8 cause Cushing's disease.

Authors:  Martin Reincke; Silviu Sbiera; Akira Hayakawa; Marily Theodoropoulou; Andrea Osswald; Felix Beuschlein; Thomas Meitinger; Emi Mizuno-Yamasaki; Kohei Kawaguchi; Yasushi Saeki; Keiji Tanaka; Thomas Wieland; Elisabeth Graf; Wolfgang Saeger; Cristina L Ronchi; Bruno Allolio; Michael Buchfelder; Tim M Strom; Martin Fassnacht; Masayuki Komada
Journal:  Nat Genet       Date:  2014-12-08       Impact factor: 38.330

3.  EGFR as a therapeutic target for human, canine, and mouse ACTH-secreting pituitary adenomas.

Authors:  Hidenori Fukuoka; Odelia Cooper; Anat Ben-Shlomo; Adam Mamelak; Song-Guang Ren; Dave Bruyette; Shlomo Melmed
Journal:  J Clin Invest       Date:  2011-11-21       Impact factor: 14.808

4.  Regulation of epidermal growth factor receptor down-regulation by UBPY-mediated deubiquitination at endosomes.

Authors:  Emi Mizuno; Takanobu Iura; Akiko Mukai; Tamotsu Yoshimori; Naomi Kitamura; Masayuki Komada
Journal:  Mol Biol Cell       Date:  2005-08-24       Impact factor: 4.138

Review 5.  Genetic mutations in sporadic pituitary adenomas--what to screen for?

Authors:  Anne-Lise Lecoq; Peter Kamenický; Anne Guiochon-Mantel; Philippe Chanson
Journal:  Nat Rev Endocrinol       Date:  2014-10-28       Impact factor: 43.330

6.  Recurrent gain-of-function USP8 mutations in Cushing's disease.

Authors:  Zeng-Yi Ma; Zhi-Jian Song; Jian-Hua Chen; Yong-Fei Wang; Shi-Qi Li; Liang-Fu Zhou; Ying Mao; Yi-Ming Li; Rong-Gui Hu; Zhao-Yun Zhang; Hong-Ying Ye; Ming Shen; Xue-Fei Shou; Zhi-Qiang Li; Hong Peng; Qing-Zhong Wang; Dai-Zhan Zhou; Xiao-Lan Qin; Jue Ji; Jie Zheng; Hong Chen; Yin Wang; Dao-Ying Geng; Wei-Jun Tang; Chao-Wei Fu; Zhi-Feng Shi; Yi-Chao Zhang; Zhao Ye; Wen-Qiang He; Qi-Lin Zhang; Qi-Sheng Tang; Rong Xie; Jia-Wei Shen; Zu-Jia Wen; Juan Zhou; Tao Wang; Shan Huang; Hui-Jia Qiu; Ni-Dan Qiao; Yi Zhang; Li Pan; Wei-Min Bao; Ying-Chao Liu; Chuan-Xin Huang; Yong-Yong Shi; Yao Zhao
Journal:  Cell Res       Date:  2015-02-13       Impact factor: 25.617
  6 in total
  5 in total

1.  USP8 Inhibitor Suppresses HER-2 Positive Gastric Cancer Cell Proliferation and Metastasis via the PI3K/AKT Signaling Pathway.

Authors:  Jiangang Sun; Dandan Shen; Yichao Zheng; Hongmei Ren; Hongmin Liu; Xiaoping Chen; Yongshun Gao
Journal:  Onco Targets Ther       Date:  2020-10-06       Impact factor: 4.147

2.  Identification of recurrent USP48 and BRAF mutations in Cushing's disease.

Authors:  Jianhua Chen; Xuemin Jian; Siyu Deng; Zengyi Ma; Xuefei Shou; Yue Shen; Qilin Zhang; Zhijian Song; Zhiqiang Li; Hong Peng; Cheng Peng; Min Chen; Cheng Luo; Dan Zhao; Zhao Ye; Ming Shen; Yichao Zhang; Juan Zhou; Aamir Fahira; Yongfei Wang; Shiqi Li; Zhaoyun Zhang; Hongying Ye; Yiming Li; Jiawei Shen; Hong Chen; Feng Tang; Zhenwei Yao; Zhifeng Shi; Chunjui Chen; Lu Xie; Ye Wang; Chaowei Fu; Ying Mao; Liangfu Zhou; Daming Gao; Hai Yan; Yao Zhao; Chuanxin Huang; Yongyong Shi
Journal:  Nat Commun       Date:  2018-08-09       Impact factor: 14.919

3.  Ultrasensitive Stress Biomarker Detection Using Polypyrrole Nanotube Coupled to a Field-Effect Transistor.

Authors:  Kyung Ho Kim; Sang Hun Lee; Sung Eun Seo; Joonwon Bae; Seon Joo Park; Oh Seok Kwon
Journal:  Micromachines (Basel)       Date:  2020-04-22       Impact factor: 2.891

4.  Development of two surgical approaches to the pituitary gland in the Horse.

Authors:  James L Carmalt; Brian A Scansen
Journal:  Vet Q       Date:  2018-12       Impact factor: 3.320

5.  A novel human tumoroid 3D model of sustained ACTH-secreting cell cultures to study critically needed therapies for Cushing's disease.

Authors:  Antonio C Fuentes-Fayos; Raúl M Luque
Journal:  EBioMedicine       Date:  2021-05-13       Impact factor: 8.143
  5 in total

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