A Sperl1, L Klimek. 1. Zentrum für Rhinologie und Allergologie Wiesbaden, An den Quellen 10, 65183, Wiesbaden, Deutschland.
Abstract
BACKGROUND: Recent research has focused on the relationship between vitamin D and allergy development. Results show that on the one hand a vitamin D deficiency can be responsible for the emergence of allergies, however, on the other hand a vitamin-D (over-) substitution was also seen in context with an increased allergy development. OBJECTIVE: This article provides an overview on the current state of research and points at the problematic aspects that accompany the assessment of these studies. RESULTS: The paradoxic effect of vitamin D is currently being explained by epigenetic programming in pregnancy, by too low vitamin-D levels or excessive supplementation in newborns. Very recently, a gender-specific impact of vitamin D is also being discussed. CONCLUSION: For a final assessment of vitamin-D effects on the emergence of allergies, further research is necessary. Due to a high level of heterogeneity among current observational studies regarding central aspects of the discussion, randomised clinical trials are recommended.
BACKGROUND: Recent research has focused on the relationship between vitamin D and allergy development. Results show that on the one hand a vitamin D deficiency can be responsible for the emergence of allergies, however, on the other hand a vitamin-D (over-) substitution was also seen in context with an increased allergy development. OBJECTIVE: This article provides an overview on the current state of research and points at the problematic aspects that accompany the assessment of these studies. RESULTS: The paradoxic effect of vitamin D is currently being explained by epigenetic programming in pregnancy, by too low vitamin-D levels or excessive supplementation in newborns. Very recently, a gender-specific impact of vitamin D is also being discussed. CONCLUSION: For a final assessment of vitamin-D effects on the emergence of allergies, further research is necessary. Due to a high level of heterogeneity among current observational studies regarding central aspects of the discussion, randomised clinical trials are recommended.
Authors: Bo L Chawes; Klaus Bønnelykke; Pia F Jensen; Ann-Marie M Schoos; Lene Heickendorff; Hans Bisgaard Journal: PLoS One Date: 2014-06-12 Impact factor: 3.240
Authors: Nina Wawro; Joachim Heinrich; Elisabeth Thiering; Jürgen Kratzsch; Beate Schaaf; Barbara Hoffmann; Irina Lehmann; Carl-Peter Bauer; Sibylle Koletzko; Andrea von Berg; Dietrich Berdel; Jakob Linseisen Journal: BMC Pediatr Date: 2014-11-25 Impact factor: 2.125