Idoia Labayen1, Javier Margareto2, Sara Maldonado-Martin3, Ilargi Gorostegi3, Maitane Illera1, María Medrano1, Lurdes Barrenechea4, Eider Larrarte2. 1. Department of Nutrition and Food Science, University of the Basque Country, UPV/EHU, Vitoria, Spain. Elikadura, Ariketa fisikoa eta Osasuna, ELIKOS, Nutrition, Exercise and Health, Research group, University of the Basque Country, UPV/EHU, Vitoria, Spain.. idoia.labayen@ehu.es. 2. Elikadura, Ariketa fisikoa eta Osasuna, ELIKOS, Nutrition, Exercise and Health, Research group, University of the Basque Country, UPV/EHU, Vitoria, Spain. Biomedical Research Area, TECNALIA, Miñano, Spain.. idoia.labayen@ehu.es. 3. Elikadura, Ariketa fisikoa eta Osasuna, ELIKOS, Nutrition, Exercise and Health, Research group, University of the Basque Country, UPV/EHU, Vitoria, Spain. Department of Physical Education and Sport, University of the Basque Country, UPV/EHU, Vitoria, Spain.. idoia.labayen@ehu.es. 4. Elikadura, Ariketa fisikoa eta Osasuna, ELIKOS, Nutrition, Exercise and Health, Research group, University of the Basque Country, UPV/EHU, Vitoria, Spain. Departament of Medicine, University of the Basque Country, UPV/EHU, Vitoria, Spain.. idoia.labayen@ehu.es.
Abstract
PURPOSE: To examine the independent and combined influence of the FTOrs9939609 and the MC4Rrs17782313 polymorphisms on changes in fat mass (FM), resting energy expenditure (REE), leptin, and thyrotropin (TSH) levels, after a 12-week energy-restricted diet intervention in non-morbid premenopausal obese women. METHODS: Fat mass (dual X-ray absorptiometry), REE (indirect calorimetry) and plasma leptin and thyrotropin levels were measured (before and after the intervention) in 77 obese (BMI: 33.9 ± 2.8 kg/m(2)) women (age: 36.8 ± 7.0y). RESULTS: There were no significant differences across FTOrs9939609 genotype groups (TT vs. A allele carriers, Ps>0.1) on changes in body mass (-8.6 ± 3.2% vs. -8.7 ± 3.3 %), FM (12.8 ± 4.7% vs. -12.9 ± 6.3%), REE (-11.3 ± 4.7 vs. -9.4 ± 8.1%), leptin (-34.1 ± 25.1% vs. -43.5 ± 24.1%) or TSH (5.2 ± 34.5% vs. -1.7 ± 27.1%) levels. Moreover, it was not observed any significant difference on changes in body mass (-8.6 ± 3.6% vs. -8.9 ± 2.6%), FM (-12.7 ± 6.1% vs. -13.4 ± 5.3%), REE (-9.8 ± 7.4% -9.4 ± 9.4%), leptin (-39.0 ± 26.9% vs. -44.8 ± 18.4%) or TSH (-1.0 ± 30.0% vs. 1.5 ± 26.5%) levels between non-C allele carriers and C allele carriers of the MC4Rrs17782313 (Ps>0.3). Finally, there were no significant difference on changes in body mass and composition, REE, leptin or TSH levels among non-risk allele carriers, carriers of the C allele risk of the MC4Rrs17782313, carriers of the A allele of the FTOrs9939609 and carriers of both risk alleles after the 12-week energy-restricted diet intervention (Ps>0.1). CONCLUSION: Carrying the A risk allele of the FTOrs9939609 and/or the C risk allele of the MC4Rrs17782313 did not influence body mass and FM loss, or REE decrease in obese women after a 12-week energy-restricted diet intervention. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
PURPOSE: To examine the independent and combined influence of the FTOrs9939609 and the MC4Rrs17782313 polymorphisms on changes in fat mass (FM), resting energy expenditure (REE), leptin, and thyrotropin (TSH) levels, after a 12-week energy-restricted diet intervention in non-morbid premenopausal obesewomen. METHODS: Fat mass (dual X-ray absorptiometry), REE (indirect calorimetry) and plasma leptin and thyrotropin levels were measured (before and after the intervention) in 77 obese (BMI: 33.9 ± 2.8 kg/m(2)) women (age: 36.8 ± 7.0y). RESULTS: There were no significant differences across FTOrs9939609 genotype groups (TT vs. A allele carriers, Ps>0.1) on changes in body mass (-8.6 ± 3.2% vs. -8.7 ± 3.3 %), FM (12.8 ± 4.7% vs. -12.9 ± 6.3%), REE (-11.3 ± 4.7 vs. -9.4 ± 8.1%), leptin (-34.1 ± 25.1% vs. -43.5 ± 24.1%) or TSH (5.2 ± 34.5% vs. -1.7 ± 27.1%) levels. Moreover, it was not observed any significant difference on changes in body mass (-8.6 ± 3.6% vs. -8.9 ± 2.6%), FM (-12.7 ± 6.1% vs. -13.4 ± 5.3%), REE (-9.8 ± 7.4% -9.4 ± 9.4%), leptin (-39.0 ± 26.9% vs. -44.8 ± 18.4%) or TSH (-1.0 ± 30.0% vs. 1.5 ± 26.5%) levels between non-C allele carriers and C allele carriers of the MC4Rrs17782313 (Ps>0.3). Finally, there were no significant difference on changes in body mass and composition, REE, leptin or TSH levels among non-risk allele carriers, carriers of the C allele risk of the MC4Rrs17782313, carriers of the A allele of the FTOrs9939609 and carriers of both risk alleles after the 12-week energy-restricted diet intervention (Ps>0.1). CONCLUSION: Carrying the A risk allele of the FTOrs9939609 and/or the C risk allele of the MC4Rrs17782313 did not influence body mass and FM loss, or REE decrease in obesewomen after a 12-week energy-restricted diet intervention. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.
Authors: James L Dorling; Daniel W Belsky; Susan B Racette; Sai Krupa Das; Eric Ravussin; Leanne M Redman; Christoph Höchsmann; Kim M Huffman; William E Kraus; Michael S Kobor; Julia L MacIsaac; David T S Lin; David L Corcoran; Corby K Martin Journal: Exp Gerontol Date: 2021-09-20 Impact factor: 4.032