Inpatient cost of treating osteoporotic fractures in mainland China: a descriptive analysis.

PURPOSE: The objective of this study was to provide new estimates on the per-admission inpatient hospital cost and per-admission length of stay (LOS) for osteoporosis-related fractures in mainland China.
MATERIALS AND METHODS: Data for inpatient hospitalization associated with at least one osteoporosis-related fracture were obtained from the nationwide China Health Insurance Research Association and were analyzed post hoc. Patients' data were included if the patients were ≥50 years old and diagnosed with osteoporosis and pathologic fracture, or osteoporosis therapy and fragility fracture by an International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) code designation, between 2008 and 2010.
RESULTS: The analysis included 830 patients (female: 77.3%; mean age: 73.4±9.8 years). The medians of the per-admission LOS and inpatient costs were 19 days and ¥18,587, respectively. Longer LOS and higher costs per admission were associated with older patients (≥70 years) compared to younger patients (<70 years). Hip fracture had the longest median LOS (22 days) and highest median cost (¥32,594) among all fracture sites. The per-hospitalization episode and per-day costs of osteoporotic fracture increased rapidly (60% and 89%, respectively) between 2008 and 2010.
CONCLUSION: The analysis showed that hospitalization cost increases were associated with increasing per-day hospitalization costs. The proportion of the costs reimbursed by health insurances increased, while the mean absolute patient copayment amounts decreased. The incidence and prevalence of osteoporosis and osteoporosis-related fractures may rise rapidly due to the projected growth of the aged population in mainland China. Therefore, the combination of greater anticipated total fractures and rising hospital costs may lead to a tremendously increased economic burden in the future.

Introduction

Estimates for current inpatient hospital length of stay (LOS) and costs due to osteoporotic fractures in mainland China remain relatively unknown except for four studies conducted in the years 2000,1 1998–2002,2 1998–2003,3 and 1998–2007.4 The consequences of osteoporotic fractures include increased morbidity, disability, and economic burden on the health care system and society.5 In mainland China, a regional study conducted between 2002 and 2006 of 7,042 healthy individuals aged 20 years and older estimated the number of individuals older than 50 years with a high risk of osteoporosis at 12.5 million (10.4%) men and 37.2 million (31.2%) women.6 Forecasts of demographic data for the ≥65-year-old Chinese population indicate that it will more than double from 115 million in 2010 to over 238 million by 2030.7 With the rapidly growing elderly population in mainland China, osteoporosis is anticipated to become highly prevalent, and it will be increasingly important to understand current hospital costs and LOS in order to plan for a more efficient allocation of resources to meet this expected growing disease burden. The aim of this study was to provide a descriptive summary of inpatient hospital cost estimates for osteoporosis-related fractures based on an analysis of retrospective data between 2008 and 2010 for per-admission inpatient hospital costs, LOS, patient copayment burden, and per-day hospital costs in mainland China. At this time, there are no existing studies utilizing the China Health Insurance Research Association (CHIRA) claims database for estimating costs from the payer perspective.

Materials and methods

This retrospective analysis identified patients with at least one hospitalization for osteoporotic fracture between 2008 and 2010 using the CHIRA claims database. This database was chosen because it is the largest nationwide claims database in mainland China, which would provide a sufficient sample size for this analysis; it is also representative of over 70 tier 1, 2, and 3 cities in mainland China, and would balance the geographic and economic differences across mainland China. However, the CHIRA database does not include rural areas and thus is not representative of rural China. Patient data collected from the CHIRA database represented a nationwide, cross-sectional sample collected annually from inpatients of sample cities, and included demographics, hospital type and tier, diagnosis, comorbidities, medications, services and dates, LOS, and insurance type. In mainland China, there are three public health insurances: the Urban Employee Basic Medical Insurance (UEBMI); the Urban Resident Basic Medical Insurance (URBMI); and the New Rural Cooperative Medical Insurance. The UEBMI covers urban employees and the URBMI covers those who are not employed (young children, students, and unemployed urban residents). Once an enrollee has been covered by the UEBMI for more than 15 years, that individual will be covered by the same medical insurance for his or her entire life (ie, the enrollee will continue to be covered by the UEBMI after retirement).

Figure 1 presents a flowchart of patients included in this study. The inclusion criteria for this study required patients to be aged ≥50 years and to have been hospitalized for osteoporotic fracture, where osteoporotic fracture was defined as a diagnosis of osteoporosis and pathologic fracture, or fragility fracture with an osteoporosis therapy. Osteoporosis with pathologic fracture and fragility fractures (vertebral, hip, nonvertebral/nonhip [NVNH], multiple fractures, or unspecified site of fracture) were identified by an International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) code diagnosis. The NVNH fracture sites included the humerus, femur, wrist, pelvis, rib, ankle, foot, and “others” (unspecified).

Figure 1

Patient flowchart.

Note: *Outliers included length of stay >400 days and hospitalization costs >¥50,000 or ≤¥300.

Abbreviations: N, total number; n, sample number.

Decision rules were imposed to screen-out potential outliers due to extremely high or low resource use or costs, if associated with clinical conditions not due to osteoporosis. For this reason, patients with severe comorbidities (such as cancer or stroke) were excluded because such comorbidities may have significantly impacted hospitalization costs and led to extremely high cost outcomes that were unrelated to osteoporosis fractures. Specifically, patients were excluded if the LOS was >400 days; if hospitalization costs were <¥300 or >¥500,000; if they had comorbidities of stroke, dementia, or incurable cancers; if fractures were related to severe trauma such as car accidents or other violence; or if fractures involved the bones of the skull, face, fingers, or toes.

Statistical analysis

Descriptive statistical methods were used to produce a profile of patients’ baseline characteristics, fracture sites, and hospitalization years for osteoporotic fracture patients. To account for non-normally distributed data, Wilcoxon rank–sum tests (for two groups) and the Kruskal–Wallis test (for >2 groups)8 were used to test and compare the LOS and total medical costs among different subgroups of osteoporotic fracture inpatients (sex, age group, and fracture sites).

The significance level was set at α=0.05, and all analyses were conducted using StataSE (version 12) and Microsoft Excel (Microsoft Corporation, Redmond, WA, USA).

Results

Patient demographics

Overall, based on the inclusion criteria, there were 830 patients with osteoporotic fractures requiring hospitalization during 2008 and 2010 (Table 1). Of the total, females comprised 77.3%, the patients’ mean age was 73.4±9.8 years, and nearly 70% were at least 70 years old. Approximately 82% were covered by UEBMI, whereas 17% were covered by URBMI;9 a small percentage, 1.3%, could not be identified with respect to insurance type. Representation by area and city level was disproportionately highest in the east (83.7%) and in provincial capitals/municipalities (81.5%), respectively. Approximately two-thirds of patients were treated in tier 3 hospitals.

Table 1

Osteoporotic fracture patient demographics

Total patients with fractureN=830	n	Distribution
Sex
Male	188	22.7%
Female	642	77.3%
Age group
All (excluding unspecified)	823	–
Mean (SD)	73.4 (9.8)
50–59 years	92	11.1%
60–69 years	152	18.3%
70–79 years	350	42.2%
80+ years	229	27.6%
Unspecified	7	0.8%
Insurance type
Employed (UEBMI)	678	81.7%
Resident (URBMI)	141	17.0%
Unspecified	11	1.3%
Area
East	695	83.7%
Center	59	7.1%
West	76	9.2%
City level
Provincial capitals/municipalities	676	81.5%
Prefecture/subprefecture cities	143	17.2%
County-level cities	11	1.3%
Hospital level
Community and township hospitals	11	1.3%
Hospital tier
1	20	2.4%
2	243	29.3%
3	556	67.0%

Abbreviations: N, number of patients in group; n, number of affected patients; SD, standard deviation; UEBMI, Urban Employee Basic Medical Insurance; URBMI, Urban Resident Basic Medical Insurance.

Fracture sites

The distribution of total fractures by year was 13%, 31%, and 56% from 2008–2010 (Table 2). Over the full 3-year period, the distribution of osteoporotic fractures by type was 32.5% (number [n] =270), 30.8% (n=256), and 31.9% (n=265) for vertebral, hip, and NVNH, respectively. The within-year distribution of fractures by type remained relatively stable over the 3 years. Overall, vertebral fractures were more often lumbar (23.9%; n=198) compared to thoracic (8.7%; n=72) (data not shown in table). The NVNH fractures occurred, overall, more often in the femur (9.2%; n=76) when compared to the humerus (5.2%; n=43); but, in general, the sample sizes were too small to make meaningful comparisons of the individual NVNH fracture sites (data not shown in table).

Table 2

Fracture sites per year, 2008–2010

Fracture site	Total		2008			2009			2010
	N=830n	%	N=107n	Within 2008%	Over 3 years 2008–2010*%	N=255n	Within 2009%	Over 3 years 2008–2010*%	N=468n	Within 2010%	Over 3 years 2008–2010*%
Vertebral	270	32.5%	31	29.0%	11.5%	83	32.5%	30.7%	156	33.3%	57.8%
Hip	256	30.8%	33	30.8%	12.9%	93	36.5%	36.3%	130	27.8%	50.8%
NVNH	265	31.9%	33	30.8%	12.5%	78	30.6%	29.4%	154	32.9%	58.1%
Multiple fractures	6	0.7%	2	1.9%	33.3%	1	0.4%	16.7%	3	0.6%	50.0%
Unspecified	33	4.0%	8	7.5%	24.2%	0	0.0%	0.0%	25	5.3%	75.8%

Note:

Percent values calculated as the current year fracture total divided by the 3-year total for the specific fracture type.

Abbreviations: N, number of patients in group; n, number of affected patients; NVNH, nonvertebral/nonhip.

Length of stay and costs associated with osteoporotic fracture

The overall median LOS was 19 days. The median LOS was similar across sexes, but were not similar for age groups (P=0.023), while statistically significant differences were found for insurance status (P=0.002) and fracture site (P=0.0001) (Table 3). The median LOS among UEBMI was 19 days, while the median LOS for nonworking residents (covered by the URBMI) was 16 days. The highest median LOS was reported for hip fractures (22 days), and was statistically significantly greater than vertebral fracture median LOS (15 days; P<0.0001) and greater than NVNH fracture median LOS (18 days; P<0.0001).

Table 3

Hospital length of stay and hospitalization costs by patient characteristics, insurance type, and fracture type, 2008–2010

	N	Mean ± SD	Median	Max	Min	Range	P-value (Kruskal–Wallis)	P-value (Wilcoxon)
Total	830	22.5±18.3	19	181	1	180
Sex								0.478
Male	188	21.5±16.1	18	126	4	122
Female	642	22.8±19.0	19	181	1	180
Age group							0.023
50–59 years	92	21.0±17.7	17	99	1	98
60–69 years	152	21.6±19.0	17	126	2	124		0.138a
70–79 years	350	23.4±18.7	19	181	1	180		0.312
80+ years	229	22.6±17.8	19	126	1	125
Unspecified	7	14.9±8.5	14	31	6	25
Insurance type							0.002
Employed (UEBMI)	678	23.3±19.1	19	181	1	180
Resident (URBMI)	141	18.7±13.9	16	93	1	92
Unspecified	11	24.6±13.3	27	43	7	36
Fracture sites							0.0001
Vertebral	270	20.2±17.6	15	126	1	125		<0.0001b
Hip	256	27.1±19.4	22	181	2	179		<0.0001c
NVNH	265	21.1±18.3	18	177	1	176		0.0528d
Multiple fractures	6	18.2±13.4	13.5	43	8	35
Unspecified	33	17.7±8.0	16	35	5	30
Hospital costs (¥)
Total	830	24,599±22,064	18,587	156,501	352
Sex								0.1454
Male	188	27,452±25,542	20,391	156,501	374
Female	642	23,763±20,886	17,787	133,700	352
Age group							0.0852
50–59 years	92	19,623±17,976	14,623	95,590	2,215
60–69 years	152	22,670±23,347	15,530	156,501	484			0.1767a
70–79 years	350	26,205±22,542	21,091	133,700	915			0.6983
80+ years	229	25,626±21,899	21,930	127,196	352
Unspecified	7	17,966±12,255	11,358	35,656	5,559
Insurance type							0.0353
Employed (UEBMI)	678	25,451±21,992	19,479	146,481	837	145,643
Resident (URBMI)	141	22,298±22,214	16,418	156,501	944	155,556
Unspecified	11	1,608±1,235	1,305	3,983	352	3,631
Fracture sites							0.0001
Vertebral	270	19,239±20,503	10,493	120,813	374	120,439		<0.0001b
Hip	256	34,202±22,867	32,594	133,700	837	132,863		<0.0001c
NVNH	265	22,034±20,084	17,185	156,501	529	155,972		0.0046d
Multiple fractures	6	27,513±35,265	8,905	80,077	352	79,725
Unspecified	33	13,440±15,195	8,599	57,325	983	56,343

Notes:

Comparison of inpatients aged 60–69 years versus those aged 80+ years;

comparison of vertebral fracture versus hip fracture;

comparison of hip fracture versus NVNH fracture;

comparison of NVNH fracture versus vertebral fracture. Exchange rate =1 RMB/CNY =0.16 USD.

Abbreviations: N, number of patients in group; SD, standard deviation; Max, maximum; Min, minimum; UEBMI, Urban Employee Basic Medical Insurance; URBMI, Urban Resident Basic Medical Insurance; NVNH, nonvertebral/nonhip; RMB, Renminbi; CNY, Chinese Yuan; USD, United States dollar.

For per-admission costs, the median cost for inpatient hospital fractures was ¥18,587. Median hospital costs were higher for men than for women (¥20,391 versus ¥17,787, respectively), but they were not statistically significantly different (P=0.1454). By age, median costs ranged from ¥14,623 in the 50–59-year age group to ¥21,930 in the 80+-year age group, but the differences were not statistically significantly different (P=0.0852). Median costs were different among UEBMI-insured employees; URBMI-insured, nonworking residents; and the nonspecified (¥19,479, ¥16,418, and ¥1,305, respectively; P=0.0353). By fracture site, hip fractures had the highest median cost (¥32,594) when compared to NVNH fractures (¥17,185) and vertebral fractures (¥10,493) (P<0.0001). The median cost differences between fracture sites were all statistically significant.

Yearly trends in length of stay and medical costs associated with osteoporotic fractures

Over the 3 years, the mean hospital LOS showed a slight decrease of approximately 9%, from 24.1 days in 2008 to 21.9 days in 2010 (Table 4). In contrast, the estimated mean hospital costs revealed a large increase of almost 60% from 2008 to 2010, with most of the increase occurring between 2008 and 2009 (44% increase from ¥16,696 to ¥24,056) (Figure 2). Along with the increasing hospital costs, insurance reimbursement increased as a proportion of the total payment, while the patient proportion of the total payment decreased. In 2008, reimbursement by the UEBMI and URBMI for osteoporotic fractures was, on average, approximately ¥8,655 or 52% (¥8,655/¥16,696). By 2010, the UEBMI and URBMI share of reimbursement rose to approximately 61% (¥16,242/¥26,701). The share of hospital payments borne by individuals fell from 48% in 2008 to 39% in 2010 (Table 4). However, on average, the absolute copayment amounts paid by individuals increased by 30% from ¥8,041 in 2008 to ¥10,460 in 2010. On a per-day basis, the average hospital costs were estimated to rise from ¥802 in 2008 by 74.3% to ¥1,397 in 2009, and by 89.2% to ¥1,517 in 2010 (Figure 3).

Table 4

Yearly trends in length of stay and costs, 2008–2010

N=830	Defined osteoporosis fractures (N=830) by day
	Hospital length of stay (days)
	Mean ± SD	Median	Max	Min	Range
Total	22.5±18.3	19	181	1	180
Year
2008	24.1±16.6	21	100	1	99
2009	22.9±18.2	19	96	1	95
2010	21.9±18.8	18	181	1	180
Hospital costs (¥)
2008	16,696±19,416	10,234	127,196	352	126,844
2009	24,056±20,673	19,817	126,287	837	125,450
2010	26,701±22,963	21,349	156,501	944	155,556
UEBMI and URBMI cover (reimbursement)
2008	8,655±9,911	4,783	50,605	19.3	50,585
2009	13,160±13,270	7,992	85,454	191	83,263
2010	16,242±17,361	9,002	105,179	0.7	105,178
Individual medical economic burden (copayment)
2008	8,041±16,062	1,025	124,604	0.00	124,604
2009	10,896±14,475	4,954	85,326	0.00	85,326
2010	10,460±15,777	4,722	153,413	0.00	153,413
Hospital costs per day
2008	802±862	506	4,741	35.3	4,706
2009	1,397±1,629	985	14,956	53	14,902
2010	1,517±1,779	1,045	27,260	90.8	27,169

Note:

Exchange rate =1 RMB/CNY =0.16 USD.

Abbreviations: SD, standard deviation; Max, maximum; Min, minimum; UEBMI, Urban Employee Basic Medical Insurance; URBMI, Urban Resident Basic Medical Insurance; RMB, Renminbi; CNY, Chinese Yuan; USD, United States dollar.

Figure 2

Average per-admission hospitalization costs and patient copayment by year.

Abbreviation: RMB, Renminbi.

Figure 3

Average per-day hospitalization costs by year.

Abbreviations: RMB, Renminbi.

To provide more information pertaining to the most recent data, an additional analysis of the 468 patients in 2010 showed the median LOS was 18 days for UEBMI versus 15 days for URBMI, and the highest median hospital cost was ¥38,746 for hip fracture (Table 5).

Table 5

Length of stay and hospitalization costs per admission, 2010

	Length of stay in 2010 (N=468) (days)					Hospitalization cost in 2010 (N=468) (¥)
	Mean ± SD	Median	Min	Max	P-value (Wilcoxon)	Mean ± SD	Median	Min	Max	P-value (Wilcoxon)
Total	21.9±18.8	18	1	181		26,701±22,963	21,349	944	156,501
Sex					0.823					0.054
Male	22.1±17.1	18	4	126		31,324±27,637	25,417	2,215	156,501
Female	21.9±19.3	18	1	181		25,213±21,070	20,396	944	133,700
Insurance type					0.003					0.013
Employed (UEBMI)	22.9±19.9	18	1	181		27,450±22,378	23,867	1,157	146,481
Resident (URBMI)	17.7±12.3	15	2	74		23,514±25,190	18,130	944	156,501
Fracture type
Vertebral	19.2±16.7	15	1	126		21,078±22,073	11,901	944	120,813
Hip	27.5±20.9	22	5	181		37,522±21,009	38,746	3,284	133,700
NVNH	20.9±19.4	17	2	177		25,417±23,112	20,722	949	156,501
Multiple fractures	11.7±4.0	11	8	16		27,336±32,392	14,401	3,410	64,197
Missing	17.1±7.0	17	5	31		13,360±14,579	7,910	1,157	49,471

Note:

Exchange rate =1 RMB/CNY =0.16 USD.

Abbreviations: N, number of patients in group; SD, standard deviation; Min, minimum; Max, Maximum; UEBMI, Urban Employee Basic Medical Insurance; URBMI, Urban Resident Basic Medical Insurance; NVNH, nonvertebral/nonhip; RMB, Renminbi; CNY, Chinese Yuan; USD, United States dollar.

Discussion

This retrospective database study analyzed CHIRA claims data from 2008–2010 to estimate hospital costs and LOS due to osteoporotic fractures reported in mainland China. The median hospital LOS and inpatient costs for all fractures were 19 days and ¥18,587, respectively. Older fracture patients (≥70 years) had longer median per-admission LOS of 19 days (P<0.01) and higher median costs of reimbursement of ¥21,528 (P<0.01) than younger patients. Hip fractures had the longest median LOS (22 days) and highest median cost (¥32,594). We also found a sharp increase in the mean hospital costs of over 44% and 60% from 2008 to 2009 and from 2008 to 2010, respectively, while the corresponding mean costs per day rose by over 74% and 89% during these periods. In addition, patient copayment, as a percentage of hospital costs, fell by 6.1% in 2010 (39.2%) compared to 2009 (45.3%), but due to overall rising hospital costs, the patients’ total out-of-pocket burden increased by 30%.

Hospital distribution was geographically unequal; there were 695 (83.7%) hospitals located in the east, 59 (7.1%) located in the center, and 76 (9.2%) located in the west. Therefore, the results and conclusions from the pooled data reported herein may not be completely applicable to all areas.

A few previous studies have reported estimates on hospital costs and LOS for fracture patients in large cities in mainland China. Retrospective data on hospital LOS and costs in the year 2000 for 2,855 patients aged 50 years and older (mean age: 73.6±9.9 years) who were hospitalized for bone fragility hip fractures in 13 districts of Shanghai, People’s Republic of China, were obtained from hospital records and were analyzed by Dai et al.1 The mean LOS for osteoporotic women was 35 days, but was longer for patients aged over 60 years and was associated with a higher mean cost of hospital stay (¥18,932, up from ¥15,082) at age 65–74 years. Only 14% of patients hospitalized for osteoporotic hip fracture received treatment for osteoporosis. Another study of hip fracture costs and LOS over 6 years in Shanghai, People’s Republic of China, was reported by Huang et al.3 While the average costs for femoral neck fracture increased from ¥13,115 in 1998 up to ¥25,867 in 2003, and the average costs for intertrochanteric fracture increased from ¥8,678 in 1998 up to ¥19,098 in 2003, the LOS for both groups did not change significantly (ranging between 16 days and 24 days) during the same 6-year period.

Similarly, Luo and Xu2 analyzed data from 90 patients with osteoporotic hip fracture who completed a questionnaire from Peking Union Medical College Hospital (Beijing, People’s Republic of China), following discharge between 1998 and 2002. There were 90 patients (29 males) and the mean ± standard deviation (SD) average age was 71.78±9.7 years. The annual economic burden per patient was ¥32,776, of which the hospital cost was ¥23,107, and it comprised 70.5% of the total cost. Unfortunately, this analysis did not present LOS data.

Another study by Cheng et al4 reported on 3,449 osteoporotic hip fracture patients (average mean ± SD age: 76.32±9.52 years) who were discharged from two hospitals in Guangzhou, People’s Republic of China, during the period between 1998 and 2007. The mean ± SD LOS was 23.59±13.48 days and hospitalization costs increased, on average, by 6.18% each year over the study period. The average (mean ± SD) inpatient costs were ¥23,520±¥17,000 and they were associated mostly with treatment (implants and materials used in surgery and wound care [52%], pharmacy intervention [25%], surgery [6%], ward expenditure [5%], radiology and physical investigation [5%], and chemistry testing [4%]). While hospitalization numbers peaked for the 70–79-year (38.45%) and 80–89-year (33.08%) age groups, inpatient costs peaked for the 60–69-year age group, with overall costs correlated significantly with LOS.

All of these fracture–cost studies predate the period of this current study, and none used nationally derived data; therefore, direct comparisons were not possible in most cases. However, for osteoporotic hip fractures occurring in mainland China, these studies indicate a similar escalation in treatment costs that were correlated with LOS.

An important strength of our study is that it used recent, nationally representative hospital data to derive new estimates on hospital LOS and costs due to osteoporotic fractures. The study provides detailed estimates by fracture type and by major socioeconomic characteristics from 2008–2010 that can be used in economic analyses. Some important limitations included the small sample sizes in some geographic areas (central and west areas, prefecture-and subprefecture-level cities, and county-level cities). The CHIRA database does not include the rural areas; therefore, it is not representative of rural China. Also, the P-values presented were not adjusted for multiplicity. Subgroups were analyzed by sex and age, but due to the cross-sectional nature of our inpatient data, it was not possible to analyze subgroups based on patient histories, such as previous fracture, cumulative glucocorticoid exposure, or other clinical risk factors for fracture, or to capture follow-up costs, such as readmission costs. In addition, because data from the CHIRA database are cross-sectional, it is not certain if the 830 patients were mutually exclusive. However, given that these patients were from a database that randomly selected from urban cities across China, the chance of the same patient having a fracture twice (or more) is very low. We did not adjust our cost estimates for inflation; however, changes in the Consumer Price Index, during the periods of 2008–2009 and 2009–2010, were -0.7% and 3.3%, respectively. Therefore, these adjustments have only negligible effects on the results. We included only those patients with a formal osteoporosis diagnosis in their medical claims, which may have led to the exclusion of legitimate, but unidentified, osteoporosis patients. Although potentially conservative, this definition was necessary to identify fractures most likely due to osteoporosis. The impacts of using alternative definitions of osteoporosis on hospital LOS and cost estimates, however, should be addressed in future studies.

Rising costs in health care are being seen in nearly every market around the world. As in other markets, in mainland China, the population is aging and more expensive health care technologies are being utilized, which may be contributing to higher health care costs. However, it is beyond the scope of this study to clearly identify and examine the determinants of these rising costs. Future research is needed to extend the current study to assess longer-term trends in costs, full fracture episode costs, and the potential underlying factors behind these costs in mainland China.

Conclusion

Our study used recent, nationally representative, cross-sectional data to provide more accurate estimates on the costs of osteoporotic fractures and trends over a 3-year period in mainland China. These new estimates are an important contribution toward understanding the potential economic burden of osteoporotic fractures in mainland China. Due to the anticipated fast-aging population in mainland China and the rising trend in hospital costs, the economic burden of osteoporotic fracture is expected to rapidly increase in the future. Proper medical management and societal precautions, as well as prevention of falls in the home, may reduce the economic burden of osteoporotic fractures.