Literature DB >> 25926388

Synthesis, reactivity, and biological activity of 5-aminouracil and its derivatives.

Raafat Mohamed Shaker1, Mohamed Abd Elrady2, Kamal Usef Sadek3.   

Abstract

The synthesis and reactions of 5-aminouracil and its derivatives are comprehensively reviewed. A brief survey of biological activities, especially chemotherapeutic and pharmacological properties, is also reported.

Entities:  

Keywords:  5-Aminouracil; Chemotherapeutic interest; Pharmacological interest; Reactivity; Synthesis

Mesh：

Substances：

Year:  2015        PMID： 25926388     DOI： 10.1007/s11030-015-9595-1

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  76 in total

1.  Structure and activity relationships of novel uracil derivatives as topical anti-inflammatory agents.

Authors:  Yoshiaki Isobe; Masanori Tobe; Yoshifumi Inoue; Masakazu Isobe; Masami Tsuchiya; Hideya Hayashi
Journal:  Bioorg Med Chem       Date:  2003-11-17       Impact factor: 3.641

2.  Insignificant inhibitory effects by pyrimidines on enterovirus propagation and their probable secondary role as inhibitors.

Authors:  A C HOLLINSHEAD
Journal:  Med Exp Int J Exp Med       Date:  1962

3.  The peculiar spectral properties of amino-substituted uracils: a combined theoretical and experimental study.

Authors:  Akos Bányász; Szilvia Karpati; Yannick Mercier; Mar Reguero; Thomas Gustavsson; Dimitra Markovitsi; Roberto Improta
Journal:  J Phys Chem B       Date:  2010-10-07       Impact factor: 2.991

4.  Experimental studies on the therapy of schistosomiasis.

Authors:  W KIKUTH; R GONNERT
Journal:  Ann Trop Med Parasitol       Date:  1948-12

5.  Studies on acyclic pyrimidines as inhibitors of mycobacteria.

Authors:  Naveen C Srivastav; Tracey Manning; Dennis Y Kunimoto; Rakesh Kumar
Journal:  Bioorg Med Chem       Date:  2006-12-23       Impact factor: 3.641

6.  Differences in mitotic cycle in various tissues of Vicia faba roots as revealed by 5-amino uracil synchronization of cell division.

Authors:  E Mattingly
Journal:  Exp Cell Res       Date:  1966-05       Impact factor: 3.905

7.  Nucleosides. 3. Studies on 5-methylamino-2'-deoxyuridine as a specific antiherpes agent.

Authors:  T Y Shen; J F McPherson; B O Linn
Journal:  J Med Chem       Date:  1966-05       Impact factor: 7.446

8.  SYNTHETIC SCHISTOSOMICIDES. IV. 5-(4-(2-DIETHYLAMINOETHYLAMINO)-1-NAPHTHYLAZO)URACIL AND RELATED (4-(AMINOALKYLAMINO)-1-NAPHTHYLAZO)HETEROCYCLIC COMPOUNDS.

Authors:  E F ELSLAGER; D B CAPPS; D H KURTZ; L M WERBEL; D F WORTH
Journal:  J Med Chem       Date:  1963-11       Impact factor: 7.446

9.  Synthesis of modified pyrimidine bases and positive impact of chemically reactive substituents on their in vitro antiproliferative activity.

Authors:  Steffi Noll; Marijeta Kralj; Lidija Suman; Holger Stephan; Ivo Piantanida
Journal:  Eur J Med Chem       Date:  2008-06-11       Impact factor: 6.514

10.  Partial Synchronization of Nuclear Divisions in Root Meristems with 5-Aminouracil.

Authors:  H H Smith; C P Fussell; B H Kugelman
Journal:  Science       Date:  1963-11-01       Impact factor: 47.728
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  2 in total

1.  5-Aminouracil and other inhibitors of DNA replication induce biphasic interphase-mitotic cells in apical root meristems of Allium cepa.

Authors:  Aneta Żabka; Konrad Winnicki; Justyna Teresa Polit; Joanna Bernasińska-Słomczewska; Janusz Maszewski
Journal:  Plant Cell Rep       Date:  2020-04-23       Impact factor: 4.570

2.  Molecular Insights into How the Dimetal Center in Dihydropyrimidinase Can Bind the Thymine Antagonist 5-Aminouracil: A Different Binding Mode from the Anticancer Drug 5-Fluorouracil.

Authors:  En-Shyh Lin; Ren-Hong Luo; Ya-Ching Yang; Cheng-Yang Huang
Journal:  Bioinorg Chem Appl       Date:  2022-02-14       Impact factor: 7.778
  2 in total

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