Mallika Punukollu1, Nadine Mushet2, Marisa Linney3, Colm Hennessy4, Michael Morton2. 1. Institute of Health and Wellbeing, College of Medical, Veterinary and Life Sciences, Caledonia House, Royal Hospital for Sick Children, University of Glasgow, Yorkhill, Glasgow, UK. 2. Liaison Psychiatry Team, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK. 3. Department of Child and Adolescent Psychiatry, Midpark Hospital, Dumfries, UK. 4. National Child Inpatient Unit, Caledonia Ward, Royal Hospital for Sick Children, Yorkhill, Glasgow, UK.
Abstract
AIM: Sydenham's chorea is a post-streptococcal, autoimmune, neuropsychiatric movement disorder. Sydenham's chorea is a major criterion for diagnosis of acute rheumatic fever with the implication of potential long-term sequelae including cardiac complications. It is well established that there is psychiatric comorbidity in Sydenham's chorea, but there are variations in the literature regarding the nature and prevalence of psychiatric diagnoses associated with Sydenham's chorea. The aim of this review was to systematically evaluate the evidence for psychiatric symptoms presenting with Sydenham's chorea. Knowledge of comorbid psychiatric symptomatology will support early diagnosis and treatment, leading to improved long-term outcomes for children with Sydenham's chorea. METHOD: The study used a systematic search strategy, using MEDLINE, MEDLINE in Process, EMBASE, and The Cochrane Library. Abstracts were screened to identify relevant papers which were then assessed further. Eligible papers were summarized. RESULTS: A total of 1429 abstracts of relevant studies were found, and 49 papers reporting neuropsychiatric symptoms in Sydenham's chorea were summarized. Obsessive-compulsive disorder was the most commonly studied, and hence reported, neuropsychiatric symptom in children with Sydenham's chorea. The studies analysed used a variety of tools to identify affected children and used different methods for analysing results. Attention-deficit-hyperactivity disorder, affective disorders, tic disorders, executive function disturbances, and psychotic features were also reported as comorbidities. INTERPRETATION: There is good evidence of neuropsychiatric comorbidities in Sydenham's chorea. In countries with a high prevalence of rheumatic fever, the early recognition of salient cognitive and psychiatric symptoms may aid in the management of Sydenham's chorea.
AIM: Sydenham's chorea is a post-streptococcal, autoimmune, neuropsychiatric movement disorder. Sydenham's chorea is a major criterion for diagnosis of acute rheumatic fever with the implication of potential long-term sequelae including cardiac complications. It is well established that there is psychiatric comorbidity in Sydenham's chorea, but there are variations in the literature regarding the nature and prevalence of psychiatric diagnoses associated with Sydenham's chorea. The aim of this review was to systematically evaluate the evidence for psychiatric symptoms presenting with Sydenham's chorea. Knowledge of comorbid psychiatric symptomatology will support early diagnosis and treatment, leading to improved long-term outcomes for children with Sydenham's chorea. METHOD: The study used a systematic search strategy, using MEDLINE, MEDLINE in Process, EMBASE, and The Cochrane Library. Abstracts were screened to identify relevant papers which were then assessed further. Eligible papers were summarized. RESULTS: A total of 1429 abstracts of relevant studies were found, and 49 papers reporting neuropsychiatric symptoms in Sydenham's chorea were summarized. Obsessive-compulsive disorder was the most commonly studied, and hence reported, neuropsychiatric symptom in children with Sydenham's chorea. The studies analysed used a variety of tools to identify affected children and used different methods for analysing results. Attention-deficit-hyperactivity disorder, affective disorders, tic disorders, executive function disturbances, and psychotic features were also reported as comorbidities. INTERPRETATION: There is good evidence of neuropsychiatric comorbidities in Sydenham's chorea. In countries with a high prevalence of rheumatic fever, the early recognition of salient cognitive and psychiatric symptoms may aid in the management of Sydenham's chorea.
Authors: Luiz Paulo Bastos Vasconcelos; Marcelle Cristina da Silva Bastos Vasconcelos; Francisco Biagio Murta E Di Flora; Flávio Augusto Paes de Oliveira; Pedro Drummond Lima; Lucas Campos Barbosa E Silva; Breno Camargos Mucelli Spolaor; José Luiz Padilha da Silva; William Antônio de Magalhães Esteves; Maria Carmo P Nunes; Antônio Lúcio Teixeira Journal: Glob Heart Date: 2022-08-29
Authors: Jacek Baj; Elżbieta Sitarz; Alicja Forma; Katarzyna Wróblewska; Hanna Karakuła-Juchnowicz Journal: Int J Mol Sci Date: 2020-02-21 Impact factor: 5.923