Literature DB >> 25926057

Copper(I) targeting in the Alzheimer's disease context: a first example using the biocompatible PTA ligand.

E Atrián-Blasco1, E Cerrada, A Conte-Daban, D Testemale, P Faller, M Laguna, C Hureau.   

Abstract

Copper(I) coordinating ligands in the Alzheimer's disease context have remained unexplored, despite the biological relevance of this redox state of the copper ion. Here, we show that the PTA ligand can remove copper from Aβ, prevent reactive oxygen species production and oligomer formation, two deleterious events in the disease's etiology.

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Year:  2015        PMID： 25926057     DOI： 10.1039/c5mt00077g

Source DB:  PubMed          Journal:  Metallomics        ISSN： 1756-5901            Impact factor:   4.526


  12 in total

1.  Evaluation of the Profile and Mechanism of Neurotoxicity of Water-Soluble [Cu(P)4]PF6 and [Au(P)4]PF6 (P = thp or PTA) Anticancer Complexes.

Authors:  C Ceresa; G Nicolini; S Semperboni; V Gandin; M Monfrini; F Avezza; P Alberti; A Bravin; M Pellei; C Santini; Guido Cavaletti
Journal:  Neurotox Res       Date:  2018-01-17       Impact factor: 3.911

2.  Role of PTA in the prevention of Cu(amyloid-β) induced ROS formation and amyloid-β oligomerisation in the presence of Zn.

Authors:  Elena Atrián-Blasco; Elena Cerrada; Peter Faller; Mariano Laguna; Christelle Hureau
Journal:  Metallomics       Date:  2019-06-19       Impact factor: 4.526

3.  N4 -Tetradentate Chelators Efficiently Regulate Copper Homeostasis and Prevent ROS Production Induced by Copper-Amyloid-β1-16.

Authors:  Weixin Zhang; Yan Liu; Christelle Hureau; Anne Robert; Bernard Meunier
Journal:  Chemistry       Date:  2018-05-15       Impact factor: 5.236

4.  A Trishistidine Pseudopeptide with Ability to Remove Both CuΙ and CuΙΙ from the Amyloid-β Peptide and to Stop the Associated ROS Formation.

Authors:  Amandine Conte-Daban; Bastien Boff; Andreza Candido Matias; Claudia N Montes Aparicio; Christelle Gateau; Colette Lebrun; Giselle Cerchiaro; Isabelle Kieffer; Stéphanie Sayen; Emmanuel Guillon; Pascale Delangle; Christelle Hureau
Journal:  Chemistry       Date:  2017-11-09       Impact factor: 5.236

Review 5.  Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level.

Authors:  Elena Atrián-Blasco; Amandine Conte-Daban; Christelle Hureau
Journal:  Dalton Trans       Date:  2017-09-22       Impact factor: 4.390

Review 6.  Chemistry of mammalian metallothioneins and their interaction with amyloidogenic peptides and proteins.

Authors:  Elena Atrián-Blasco; Alice Santoro; Dean L Pountney; Gabriele Meloni; Christelle Hureau; Peter Faller
Journal:  Chem Soc Rev       Date:  2017-12-11       Impact factor: 54.564

7.  Ascorbate Oxidation by Cu(Amyloid-β) Complexes: Determination of the Intrinsic Rate as a Function of Alterations in the Peptide Sequence Revealing Key Residues for Reactive Oxygen Species Production.

Authors:  Elena Atrián-Blasco; Melisa Del Barrio; Peter Faller; Christelle Hureau
Journal:  Anal Chem       Date:  2018-04-12       Impact factor: 6.986

8.  Is ascorbate Dr Jekyll or Mr Hyde in the Cu(Aβ) mediated oxidative stress linked to Alzheimer's disease?

Authors:  Clémence Cheignon; Fabrice Collin; Peter Faller; Christelle Hureau
Journal:  Dalton Trans       Date:  2016-08-09       Impact factor: 4.390

Review 9.  Role of Copper in the Onset of Alzheimer's Disease Compared to Other Metals.

Authors:  Soghra Bagheri; Rosanna Squitti; Thomas Haertlé; Mariacristina Siotto; Ali A Saboury
Journal:  Front Aging Neurosci       Date:  2018-01-23       Impact factor: 5.750

10.  Identification of key structural features of the elusive Cu-Aβ complex that generates ROS in Alzheimer's disease.

Authors:  Clémence Cheignon; Megan Jones; Elena Atrián-Blasco; Isabelle Kieffer; Peter Faller; Fabrice Collin; Christelle Hureau
Journal:  Chem Sci       Date:  2017-05-04       Impact factor: 9.825
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