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Literature DB >> 25925582

E-cadherin junctions as active mechanical integrators in tissue dynamics.

Abstract

During epithelial morphogenesis, E-cadherin adhesive junctions play an important part in mechanically coupling the contractile cortices of cells together, thereby distributing the stresses that drive cell rearrangements at both local and tissue levels. Here we discuss the concept that cellular contractility and E-cadherin-based adhesion are functionally integrated by biomechanical feedback pathways that operate on molecular, cellular and tissue scales.

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Year: 2015 PMID： 25925582 DOI： 10.1038/ncb3136

Source DB: PubMed Journal: Nat Cell Biol ISSN： 1465-7392 Impact factor: 28.824

117 in total

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