Literature DB >> 25925559

Roles of Natural Compounds from Medicinal Plants in Cancer Treatment: Structure and Mode of Action at Molecular Level.

Mahmood Rasool, Arif Malik, Abdul Manan, Mahwish Arooj, Mahmood Husain Qazi, Mohammad Amjad Kamal, Ishfaq Ahmed Sheikh, Siew Hua Gan, Muhammad Asif, Muhammad Imran Naseer1.   

Abstract

Every year, cancer takes the life of millions of people. Conventional treatments have produced unsatisfactory results for some types of cancer, and the side effects are extensive, leading to a shift in the focus of treatment towards alternative medicines. Indeed, medicinal plants have long been investigated by scientists for their anti-cancer properties. Some phytochemicals that are important active constituents of plants, including catechins, ursolic acid, silymarin, glycyrrhizin, ellagic acid, gallic acid and various types of flavonoids, have shown promise in future cancer management. The current review covers various aspects of cancer treatment based on medicinal plants at molecular level and sheds light on their structures and modes of action.

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Year:  2015        PMID: 25925559     DOI: 10.2174/1573406411666150430120038

Source DB:  PubMed          Journal:  Med Chem        ISSN: 1573-4064            Impact factor:   2.745


  4 in total

1.  W346 inhibits cell growth, invasion, induces cycle arrest and potentiates apoptosis in human gastric cancer cells in vitro through the NF-κB signaling pathway.

Authors:  Yiqun Xia; Bixia Weng; Zhankun Wang; Yanting Kang; Lingyi Shi; Guanqun Huang; Shilong Ying; Xiaojing Du; Qiuxiang Chen; Rong Jin; Jianzhang Wu; Guang Liang
Journal:  Tumour Biol       Date:  2015-10-31

Review 2.  Astragalin: A Bioactive Phytochemical with Potential Therapeutic Activities.

Authors:  Ammara Riaz; Azhar Rasul; Ghulam Hussain; Muhammad Kashif Zahoor; Farhat Jabeen; Zinayyera Subhani; Tahira Younis; Muhammad Ali; Iqra Sarfraz; Zeliha Selamoglu
Journal:  Adv Pharmacol Sci       Date:  2018-05-02

3.  Gallic acid-gold nanoparticles enhance radiation-induced cell death of human glioma U251 cells.

Authors:  Zhou Jing; Minghe Li; Hongyuan Wang; Zhuo Yang; Shaolong Zhou; Jian Ma; Enping Meng; Hengwei Zhang; Wulong Liang; Weihua Hu; Xinjun Wang; Xudong Fu
Journal:  IUBMB Life       Date:  2020-12-28       Impact factor: 3.885

4.  Fisetin Inhibited Growth and Metastasis of Triple-Negative Breast Cancer by Reversing Epithelial-to-Mesenchymal Transition via PTEN/Akt/GSK3β Signal Pathway.

Authors:  Jie Li; Xia Gong; Rong Jiang; Dan Lin; Tao Zhou; Aijie Zhang; Hongzhong Li; Xiang Zhang; Jingyuan Wan; Ge Kuang; Hongyuan Li
Journal:  Front Pharmacol       Date:  2018-07-31       Impact factor: 5.810

  4 in total

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