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Literature DB >> 25925225

Anti-proliferative activity of hop-derived prenylflavonoids against human cancer cell lines.

Christian Busch¹, Seema Noor, Christian Leischner, Markus Burkard, Ulrich M Lauer, Sascha Venturelli.

Abstract

Flavonoids form a substantial group of secondary plant metabolites that display several health-promoting effects. Therefore, prenylflavonoids, a subclass of flavonoids, have attracted increasing attention. Here, we investigated the possible anti-cancer potential of 6-prenylnaringenin (6-PN) and 8-prenylnaringenin (8-PN), two prenylflavonoids present in hops and beer and demonstrate an unexpectedly pronounced, dose-dependent reduction of cellular proliferation of human PC-3 prostate cancer and UO.31 renal carcinoma cells upon treatment. Based on these findings 6-PN and 8-PN are currently further clinically evaluated in detail.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2015 PMID： 25925225 DOI： 10.1007/s10354-015-0355-8

Source DB: PubMed Journal: Wien Med Wochenschr ISSN： 0043-5341

9 in total

1. Identification of a potent phytoestrogen in hops (Humulus lupulus L.) and beer.

Authors: S R Milligan; J C Kalita; A Heyerick; H Rong; L De Cooman; D De Keukeleire
Journal: J Clin Endocrinol Metab Date: 1999-06 Impact factor: 5.958

Review 2. Xanthohumol and related prenylflavonoids from hops and beer: to your good health!

Authors: Jan F Stevens; Jonathan E Page
Journal: Phytochemistry Date: 2004-05 Impact factor: 4.072

3. Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.

Authors: C L Miranda; G L Aponso; J F Stevens; M L Deinzer; D R Buhler
Journal: Cancer Lett Date: 2000-02-28 Impact factor: 8.679

4. The prenylflavonoid isoxanthohumol from hops (Humulus lupulus L.) is activated into the potent phytoestrogen 8-prenylnaringenin in vitro and in the human intestine.

Authors: Sam Possemiers; Selin Bolca; Charlotte Grootaert; Arne Heyerick; Karel Decroos; Willem Dhooge; Denis De Keukeleire; Sylvie Rabot; Willy Verstraete; Tom Van de Wiele
Journal: J Nutr Date: 2006-07 Impact factor: 4.798

Review 5. Advances in flavonoid research since 1992.

Authors: J B Harborne; C A Williams
Journal: Phytochemistry Date: 2000-11 Impact factor: 4.072

6. Quantitative analysis of xanthohumol and related prenylflavonoids in hops and beer by liquid chromatography-tandem mass spectrometry.

Authors: J F Stevens; A W Taylor; M L Deinzer
Journal: J Chromatogr A Date: 1999-02-05 Impact factor: 4.759

7. Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.

Authors: C L Miranda; J F Stevens; A Helmrich; M C Henderson; R J Rodriguez; Y H Yang; M L Deinzer; D W Barnes; D R Buhler
Journal: Food Chem Toxicol Date: 1999-04 Impact factor: 6.023

Review 8. Prenylation of aromatic compounds, a key diversification of plant secondary metabolites.

Authors: Kazufumi Yazaki; Kanako Sasaki; Yusuke Tsurumaru
Journal: Phytochemistry Date: 2009-10-12 Impact factor: 4.072

9. Prenylflavonoids: a new class of non-steroidal phytoestrogen (Part 1). Isolation of 8-isopentenylnaringenin and an initial study on its structure-activity relationship.

Authors: M Kitaoka; H Kadokawa; M Sugano; K Ichikawa; M Taki; S Takaishi; Y Iijima; S Tsutsumi; M Boriboon; T Akiyama
Journal: Planta Med Date: 1998-08 Impact factor: 3.352

9 in total

4 in total