PURPOSE: To evaluate the efficacy and safety of intravitreal implant of dexamethasone (Ozurdex®) in diabetic macular edema (DME). METHODS: This was a retrospective multicenter noncomparative study. Seventy-eight patients with DME followed for at least 6 months were included (P1.5 Network). Best-corrected visual acuity (BCVA), central retinal thickness (CRT), intraocular pressure (IOP) and cataract progression were studied at baseline and then at 1, 2, 4 and 6 months. RESULTS: The mean CRT decrease from baseline was 145.2 µm at 6 months. The mean BCVA improvement from baseline was 6.7 at 6 months. An increase in IOP was observed for 11.7% of patients, and all patients were managed by topical treatment. No glaucoma or cataract surgery was necessary, and no endophthalmitis was reported. CONCLUSIONS: One injection of Ozurdex has an anatomical and functional effectiveness for the treatment of DME. Side effects were rare and manageable in our practice.
PURPOSE: To evaluate the efficacy and safety of intravitreal implant of dexamethasone (Ozurdex®) in diabetic macular edema (DME). METHODS: This was a retrospective multicenter noncomparative study. Seventy-eight patients with DME followed for at least 6 months were included (P1.5 Network). Best-corrected visual acuity (BCVA), central retinal thickness (CRT), intraocular pressure (IOP) and cataract progression were studied at baseline and then at 1, 2, 4 and 6 months. RESULTS: The mean CRT decrease from baseline was 145.2 µm at 6 months. The mean BCVA improvement from baseline was 6.7 at 6 months. An increase in IOP was observed for 11.7% of patients, and all patients were managed by topical treatment. No glaucoma or cataract surgery was necessary, and no endophthalmitis was reported. CONCLUSIONS: One injection of Ozurdex has an anatomical and functional effectiveness for the treatment of DME. Side effects were rare and manageable in our practice.
Authors: Leonardo Mastropasqua; Silvio Di Staso; Rossella D'Aloisio; Alessandra Mastropasqua; Luca Di Antonio; Alfonso Senatore; Marco Ciancaglini; Marta Di Nicola; Giuseppe Di Martino; Daniele Tognetto; Lisa Toto Journal: Int J Ophthalmol Date: 2019-10-18 Impact factor: 1.779
Authors: Javier Zarranz-Ventura; Barbara Romero-Núñez; Carolina Bernal-Morales; Daniel Velazquez-Villoria; Anna Sala-Puigdollers; Marc Figueras-Roca; Sergio Copete; Laura Distefano; Anna Boixadera; Jose García-Arumi; Alfredo Adan Journal: BMC Ophthalmol Date: 2020-11-11 Impact factor: 2.209