Literature DB >> 25921418

Management of metastatic pancreatic cancer: Current treatment options and potential new therapeutic targets.

Francesco Sclafani1, Ridhima Iyer1, David Cunningham1, Naureen Starling2.   

Abstract

Pancreatic ductal adenocarcinoma is a malignancy with a poor prognosis, with the majority of patients diagnosed with advanced disease on presentation. Treatment options remain limited with little progress over the last 40 years. This review will focus on the current management of metastatic pancreatic ductal adenocarcinoma, with a discussion of new and future treatment strategies based on an improved understanding of tumour biology and mechanisms of pathogenesis.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  FOLFIRINOX; Gemcitabine; Nab-paclitaxel; Nanoliposomal irinotecan; Pancreatic adenocarcinoma; Pancreatic cancer; Stroma

Mesh：

Year:  2015        PMID： 25921418     DOI： 10.1016/j.critrevonc.2015.03.008

Source DB:  PubMed          Journal:  Crit Rev Oncol Hematol        ISSN： 1040-8428            Impact factor:   6.312


  12 in total

Review 1.  Liposomal irinotecan in gemcitabine-refractory metastatic pancreatic cancer: efficacy, safety and place in therapy.

Authors:  Emma Kipps; Kate Young; Naureen Starling
Journal:  Ther Adv Med Oncol       Date:  2017-03-01       Impact factor: 8.168

2.  Regulation of HIF1α under Hypoxia by APE1/Ref-1 Impacts CA9 Expression: Dual Targeting in Patient-Derived 3D Pancreatic Cancer Models.

Authors:  Derek P Logsdon; Michelle Grimard; Meihua Luo; Safi Shahda; Yanlin Jiang; Yan Tong; Zhangsheng Yu; Nicholas Zyromski; Ernestina Schipani; Fabrizio Carta; Claudiu T Supuran; Murray Korc; Mircea Ivan; Mark R Kelley; Melissa L Fishel
Journal:  Mol Cancer Ther       Date:  2016-08-17       Impact factor: 6.261

3.  Rutin Promotes Pancreatic Cancer Cell Apoptosis by Upregulating miRNA-877-3p Expression.

Authors:  Mingxing Huo; Aowen Xia; Wenwen Cheng; Mengjie Zhou; Jiankang Wang; Tiantian Shi; Cifeng Cai; Wenqi Jin; Meiliang Zhou; Yueling Liao; Zhiyong Liao
Journal:  Molecules       Date:  2022-03-31       Impact factor: 4.411

4.  Interleukin-15 stimulates natural killer cell-mediated killing of both human pancreatic cancer and stellate cells.

Authors:  Jonas R M Van Audenaerde; Jorrit De Waele; Elly Marcq; Jinthe Van Loenhout; Eva Lion; Johan M J Van den Bergh; Ralf Jesenofsky; Atsushi Masamune; Geert Roeyen; Patrick Pauwels; Filip Lardon; Marc Peeters; Evelien L J Smits
Journal:  Oncotarget       Date:  2017-05-25

5.  MiR-590 Suppresses Proliferation and Induces Apoptosis in Pancreatic Cancer by Targeting High Mobility Group A2.

Authors:  Ya-Dong Wang; Jia-Ding Mao; Jun-Feng Wang; Mao-Qi Xu
Journal:  Technol Cancer Res Treat       Date:  2020 Jan-Dec

6.  Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway.

Authors:  Xiangli Meng; Peng Liu; Yunhao Wu; Xinlu Liu; Yinpeng Huang; Boqiang Yu; Jiahong Han; Haoyi Jin; Xiaodong Tan
Journal:  Bosn J Basic Med Sci       Date:  2020-02-05       Impact factor: 3.363

7.  MiR-200a Suppresses the Proliferation and Metastasis in Pancreatic Ductal Adenocarcinoma through Downregulation of DEK Gene.

Authors:  Xiaoyu Wu; Guannan Wu; Zhenfeng Wu; Xuequan Yao; Gang Li
Journal:  Transl Oncol       Date:  2016-02       Impact factor: 4.243

8.  Pancreatic cancer presenting as colonic disease. A rare case report.

Authors:  Sara Tavares Nogueira; Bruno Lima Pinto; Eduardo Faria Silva; Hermano Anjos Garcia; Francisco Carneiro
Journal:  Int J Surg Case Rep       Date:  2018-02-09

9.  Palmatine suppresses glutamine-mediated interaction between pancreatic cancer and stellate cells through simultaneous inhibition of survivin and COL1A1.

Authors:  Divya Chakravarthy; Amanda R Muñoz; Angel Su; Rosa F Hwang; Brian R Keppler; Daniel E Chan; Glenn Halff; Rita Ghosh; Addanki P Kumar
Journal:  Cancer Lett       Date:  2018-04-10       Impact factor: 8.679

10.  EZH2-Mediated microRNA-139-5p Regulates Epithelial-Mesenchymal Transition and Lymph Node Metastasis of Pancreatic Cancer.

Authors:  Jin Ma; Jun Zhang; Yuan-Chi Weng; Jian-Cheng Wang
Journal:  Mol Cells       Date:  2018-09-18       Impact factor: 5.034
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