Literature DB >> 25921225

The synthesis of new amphiphilic p-tert-butylthiacalix[4]arenes containing peptide fragments and their interaction with DNA.

Pavel L Padnya1, Elena A Andreyko, Olga A Mostovaya, Ildar Kh Rizvanov, Ivan I Stoikov.   

Abstract

New water-soluble p-tert-butylthiacalix[4]arenes containing peptide and quaternary ammonium fragments in cone and 1,3-alternate conformations were synthesized and characterized. The interaction of the macrocycles with DNA was studied by UV-spectroscopy, DLS and TEM. It was shown that the interaction of the self-associates based on p-tert-butylthiacalix[4]arenes tetrasubstituted at the lower rim with glycine and quaternary ammonium fragments in cone and 1,3-alternate conformations with DNA led to the formation of particles of about 99-192 nm in size.

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Year:  2015        PMID： 25921225     DOI： 10.1039/c5ob00548e

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  4 in total

1.  Self-assembly of chiral fluorescent nanoparticles based on water-soluble L-tryptophan derivatives of p-tert-butylthiacalix[4]arene.

Authors:  Pavel L Padnya; Irina A Khripunova; Olga A Mostovaya; Timur A Mukhametzyanov; Vladimir G Evtugyn; Vyacheslav V Vorobev; Yuri N Osin; Ivan I Stoikov
Journal:  Beilstein J Nanotechnol       Date:  2017-09-04       Impact factor: 3.649

2.  PAMAM-calix-dendrimers: Synthesis and Thiacalixarene Conformation Effect on DNA Binding.

Authors:  Olga Mostovaya; Pavel Padnya; Igor Shiabiev; Timur Mukhametzyanov; Ivan Stoikov
Journal:  Int J Mol Sci       Date:  2021-11-02       Impact factor: 5.923

3.  Structure-Activity Relationship of the Thiacalix[4]arenes Family with Sulfobetaine Fragments: Self-Assembly and Cytotoxic Effect against Cancer Cell Lines.

Authors:  Luidmila Yakimova; Aisylu Kunafina; Aigul Nugmanova; Pavel Padnya; Alexandra Voloshina; Konstantin Petrov; Ivan Stoikov
Journal:  Molecules       Date:  2022-02-17       Impact factor: 4.411

4.  Albumin/Thiacalix[4]arene Nanoparticles as Potential Therapeutic Systems: Role of the Macrocycle for Stabilization of Monomeric Protein and Self-Assembly with Ciprofloxacin.

Authors:  Luidmila Yakimova; Aisylu Kunafina; Olga Mostovaya; Pavel Padnya; Timur Mukhametzyanov; Alexandra Voloshina; Konstantin Petrov; Artur Boldyrev; Ivan Stoikov
Journal:  Int J Mol Sci       Date:  2022-09-02       Impact factor: 6.208
  4 in total

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