| Literature DB >> 25920937 |
Natario L Couser1,2,3, Maheer M Masood4, Natasha T Strande3, Ann Katherine M Foreman3, Kristy Crooks3,5, Karen E Weck3,5, Mei Lu5, Kirk C Wilhelmsen3, Myra Roche2,3, James P Evans3, Jonathan S Berg3, Cynthia M Powell2,3.
Abstract
The Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 1 (MCAHS1) has been described in two families to date. We describe a 2-year-old Mexican American boy with the syndrome and additional manifestations not yet reported as part of the phenotype. The patient presented with severe hypotonia, microphallus and left cryptorchidism, and was later diagnosed with epilepsy and severe cortical visual impairment. He also had supernumerary nipples, pectus excavatum, a short upturned nose, fleshy ear lobes, and a right auricular pit. Massively parallel exome sequencing and analysis revealed two novel compound heterozygous missense (Trp136Gly and Ser859Thr) variants in the PIGN gene. This report extends and further defines the phenotype of this syndrome.Entities:
Keywords: North Carolina Clinical Genomic Evaluation by NextGen Exome Sequencing (NCGENES); PIGN gene; exome sequencing; multiple congenital anomalies-hypotonia-seizures syndrome-1(MCAHS1)
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Year: 2015 PMID： 25920937 PMCID： PMC6108425 DOI： 10.1002/ajmg.a.37129
Source DB: PubMed Journal: Am J Med Genet A ISSN： 1552-4825 Impact factor: 2.802