Kevin D Harkins1, Junzhong Xu1,2, Adrienne N Dula1,2, Ke Li1, William M Valentine3, Daniel F Gochberg1,2,4, John C Gore1,2,4,5,6, Mark D Does1,2,5,7. 1. Institute of Imaging Science, Vanderbilt University, Nashville, Tennessee, USA. 2. Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, Tennessee, USA. 3. Department of Pathology, Vanderbilt University, Nashville, Tennessee, USA. 4. Department of Physics and Astronomy, Vanderbilt University, Nashville, Tennessee, USA. 5. Department of Biomedical Engineering, Vanderbilt University, Nashville, Tennessee, USA. 6. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA. 7. Department of Electrical Engineering, Vanderbilt University, Nashville, Tennessee, USA.
Abstract
PURPOSE: Several studies have shown strong correlations between myelin content and T1 within the brain, and have even suggested that T1 can be used to estimate myelin content. However, other micro-anatomical features such as compartment size are known to affect longitudinal relaxation rates, similar to compartment size effects in porous media. METHODS: T1 measurements were compared with measured or otherwise published axon size measurements in white matter tracts of the rat spinal cord, rat brain, and human brain. RESULTS: In both ex vivo and in vivo studies, correlations were present between the relaxation rate 1/T1 and axon size across regions of rat spinal cord with nearly equal myelin content. CONCLUSION: While myelination is likely the dominant determinant of T1 in white matter, variations in white matter microstructure, independent of myelin volume fraction, may also be reflected in T1 differences between regions or subjects.
PURPOSE: Several studies have shown strong correlations between myelin content and T1 within the brain, and have even suggested that T1 can be used to estimate myelin content. However, other micro-anatomical features such as compartment size are known to affect longitudinal relaxation rates, similar to compartment size effects in porous media. METHODS: T1 measurements were compared with measured or otherwise published axon size measurements in white matter tracts of the rat spinal cord, rat brain, and human brain. RESULTS: In both ex vivo and in vivo studies, correlations were present between the relaxation rate 1/T1 and axon size across regions of rat spinal cord with nearly equal myelin content. CONCLUSION: While myelination is likely the dominant determinant of T1 in white matter, variations in white matter microstructure, independent of myelin volume fraction, may also be reflected in T1 differences between regions or subjects.
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