Literature DB >> 2591993

The rarity of liver toxicity in patients treated with coumarin (1,2-benzopyrone).

D Cox1, R O'Kennedy, R D Thornes.   

Abstract

1. Two thousand, one hundred and seventy-three patients with cancer or chronic infections were treated with coumarin in a clinical trial. 2. 0.37% of these patients developed elevated liver enzyme levels during therapy with coumarin. 3. This hepatitis was probably a form of idiosyncratic hepatotoxicity and may have been immune in origin.

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Year:  1989        PMID： 2591993     DOI： 10.1177/096032718900800612

Source DB:  PubMed          Journal:  Hum Toxicol        ISSN： 0144-5952


  8 in total

1.  Hepatotoxicity associated with herbal tablets.

Authors:  P A De Smet; A J Van den Eertwegh; W Lesterhuis; B H Stricker
Journal:  BMJ       Date:  1996-07-13

2.  Side-effects of coumarin.

Authors:  L Morrison; P D Welsby
Journal:  Postgrad Med J       Date:  1995-11       Impact factor: 2.401

Review 3.  A review of coumarin derivatives in pharmacotherapy of breast cancer.

Authors:  Musiliyu A Musa; John S Cooperwood; M Omar F Khan
Journal:  Curr Med Chem       Date:  2008       Impact factor: 4.530

4.  Treatment with coumarin to prevent or delay recurrence of malignant melanoma.

Authors:  R D Thornes; L Daly; G Lynch; B Breslin; H Browne; H Y Browne; T Corrigan; P Daly; G Edwards; E Gaffney
Journal:  J Cancer Res Clin Oncol       Date:  1994       Impact factor: 4.553

5.  Antioxidant Activities of 4-Methylumbelliferone Derivatives.

Authors:  Yasameen K Al-Majedy; Ahmed A Al-Amiery; Abdul Amir H Kadhum; Abu Bakar Mohamad
Journal:  PLoS One       Date:  2016-05-31       Impact factor: 3.240

6.  Combined Risk Assessment of Food-derived Coumarin with in Silico Approaches.

Authors:  Takashi Yamada; Naruo Katsutani; Taeko Maruyama; Tomoko Kawamura; Hiroshi Yamazaki; Norie Murayama; Weida Tong; Yasushi Yamazoe; Akihiko Hirose
Journal:  Food Saf (Tokyo)       Date:  2022-09-23

7.  Pulchrin A, a New Natural Coumarin Derivative of Enicosanthellum pulchrum, Induces Apoptosis in Ovarian Cancer Cells via Intrinsic Pathway.

Authors:  Noraziah Nordin; Mehran Fadaeinasab; Syam Mohan; Najihah Mohd Hashim; Rozana Othman; Hamed Karimian; Venus Iman; Noorlela Ramli; Hapipah Mohd Ali; Nazia Abdul Majid
Journal:  PLoS One       Date:  2016-05-02       Impact factor: 3.240

8.  Single-cell microinjection assay indicates that 7-hydroxycoumarin induces rapid activation of caspase-3 in A549 cancer cells.

Authors:  Maribel Soto-Nuñez; Karen Azucena Díaz-Morales; Patricia Cuautle-Rodríguez; Víctor Torres-Flores; José Sullivan López-González; Juan José Mandoki-Weitzner; Juan Arcadio Molina-Guarneros
Journal:  Exp Ther Med       Date:  2015-09-23       Impact factor: 2.447
  8 in total

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