Brigid Gregg1, Crystal G Connor2, Katrina J Ruedy3, Roy W Beck2, Craig Kollman2, Desmond Schatz4, Eda Cengiz5, Breanne Harris6, William V Tamborlane5, Georgeanna J Klingensmith7, Joyce M Lee8. 1. Department of Pediatric Endocrinology, Mott Children's Hospital, University of Michigan, Ann Arbor, MI. 2. Jaeb Center for Health Research, Tampa, FL. 3. Jaeb Center for Health Research, Tampa, FL. Electronic address: pdc@jaeb.org. 4. Pediatric Endocrinology, University of Florida, Gainesville, FL. 5. Pediatric Endocrinology, Yale University, New Haven, CT. 6. Pediatric Endocrinology, Stanford University, Stanford, CA. 7. Department of Pediatrics, Barbara Davis Center for Childhood Diabetes, University of Colorado, Aurora, CO. 8. Department of Pediatric Endocrinology, Mott Children's Hospital, University of Michigan, Ann Arbor, MI; Child Health Evaluation and Research Unit, University of Michigan, Ann Arbor, MI.
Abstract
OBJECTIVES: To describe changes in weight and body mass index (BMI) during the first year following diagnosis of type 1 diabetes (T1D) and associations with demographic and clinical characteristics. STUDY DESIGN: The Pediatric Diabetes Consortium includes 7 US centers with prospective longitudinal data from initial T1D diagnosis. This analysis includes 530 youth with diabetes duration of ≥1 year and measures of BMI at 3 and 12 months after diagnosis. BMI trajectory of participants and relationships between the change in BMI z-score from baseline (3 months) to 12 months with demographic characteristics, hemoglobin A1c at baseline, and insulin delivery mode at baseline were evaluated. RESULTS: As a group, BMI z-scores increased sharply from diagnosis for 1-3 months but remained relatively stable from +0.51 at 3 months to +0.48 at 12 months. Children aged 2-<5 years experienced a significant positive change in BMI z-score between 3 and 12 months, and there was a similar trend among girls that did not reach statistical significance. No significant differences were found for race, socioeconomic status, or insulin delivery mode. CONCLUSIONS: These data suggest that increased BMI during the first year of treatment of most youth with T1D reflects regain of weight lost before diagnosis. There is, however, a propensity toward additional weight gain in younger children and girls.
OBJECTIVES: To describe changes in weight and body mass index (BMI) during the first year following diagnosis of type 1 diabetes (T1D) and associations with demographic and clinical characteristics. STUDY DESIGN: The Pediatric Diabetes Consortium includes 7 US centers with prospective longitudinal data from initial T1D diagnosis. This analysis includes 530 youth with diabetes duration of ≥1 year and measures of BMI at 3 and 12 months after diagnosis. BMI trajectory of participants and relationships between the change in BMI z-score from baseline (3 months) to 12 months with demographic characteristics, hemoglobin A1c at baseline, and insulin delivery mode at baseline were evaluated. RESULTS: As a group, BMI z-scores increased sharply from diagnosis for 1-3 months but remained relatively stable from +0.51 at 3 months to +0.48 at 12 months. Children aged 2-<5 years experienced a significant positive change in BMI z-score between 3 and 12 months, and there was a similar trend among girls that did not reach statistical significance. No significant differences were found for race, socioeconomic status, or insulin delivery mode. CONCLUSIONS: These data suggest that increased BMI during the first year of treatment of most youth with T1D reflects regain of weight lost before diagnosis. There is, however, a propensity toward additional weight gain in younger children and girls.
Authors: Anna R Kahkoska; Christina M Shay; Sarah C Couch; Jamie Crandell; Dana Dabelea; Evgenia Gourgari; Jean M Lawrence; Angela D Liese; Catherine Pihoker; Beth A Reboussin; Natalie The; Elizabeth J Mayer-Davis Journal: Pediatr Diabetes Date: 2018-09-14 Impact factor: 3.409
Authors: Anna R Kahkoska; Crystal T Nguyen; Linda A Adair; Allison E Aiello; Kyle S Burger; John B Buse; Dana Dabelea; Lawrence M Dolan; Faisal S Malik; Amy K Mottl; Catherine Pihoker; Beth A Reboussin; Katherine A Sauder; Michael R Kosorok; Elizabeth J Mayer-Davis Journal: J Clin Endocrinol Metab Date: 2019-12-01 Impact factor: 6.134
Authors: Anna R Kahkoska; Angelica Cristello Sarteau; Daria Igudesman; Beth A Reboussin; Dana Dabelea; Lawrence M Dolan; Elizabeth Jensen; R Paul Wadwa; Catherine Pihoker; Elizabeth J Mayer-Davis Journal: J Diabetes Res Date: 2022-01-28 Impact factor: 4.011