Chike Onwuneme1, Fidelma Martin2, Roberta McCarthy2, Aoife Carroll3, Ricardo Segurado4, John Murphy5, Anne Twomey2, Nuala Murphy3, Mark Kilbane6, Malachi McKenna7, Eleanor Molloy8. 1. Department of Neonatology, National Maternity Hospital, Dublin, Ireland; Department of Endocrinology, Children's University Hospital, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland. 2. Department of Neonatology, National Maternity Hospital, Dublin, Ireland. 3. Department of Endocrinology, Children's University Hospital, Dublin, Ireland. 4. Centre for Support and Training in Analysis and Research, School of Public Health, Physiotherapy, and Population Science, University College Dublin, Dublin, Ireland. 5. Department of Neonatology, National Maternity Hospital, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; Department of Pediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland. 6. Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland. 7. School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; Department of Endocrinology, St Vincent's University Hospital, Dublin, Ireland. 8. Department of Neonatology, National Maternity Hospital, Dublin, Ireland; School of Medicine and Medical Sciences, University College Dublin, Dublin, Ireland; Department of Pediatrics, Royal College of Surgeons in Ireland, Dublin, Ireland; Department of Neonatology, Our Lady's Children's Hospital, Dublin, Ireland; Department of Pediatrics, Trinity College, Dublin, Ireland. Electronic address: elesean@hotmail.com.
Abstract
OBJECTIVE: To assess the association between serum 25-hydroxyvitamin D (25OHD) levels and outcomes in preterm infants (<32 weeks gestation). STUDY DESIGN: Serum 25OHD was measured in mothers and their infants within 24 hours of birth, before the start of enteral vitamin D supplementation, and at discharge from the neonatal intensive care unit. We evaluated the associations between vitamin D status and various early preterm outcomes. RESULTS: Ninety-four preterm infants and their mothers were included; 92% of the infants had a 25OHD level≤50 nmol/L (20 ng/mL), and 64% had a 25OHD level<30 nmol/L (12 ng/mL). A low 25OHD level (<30 nmol/L) in preterm infants at birth was associated with increased oxygen requirement (P=.008), increased duration of intermittent positive-pressure ventilation during resuscitation at delivery (P=.032), and greater need for assisted ventilation (P=.013). CONCLUSION: We observed a high prevalence of low 25OHD (<30 nmol/L), and found an association between vitamin D status and acute respiratory morbidity in preterm infants after birth.
OBJECTIVE: To assess the association between serum 25-hydroxyvitamin D (25OHD) levels and outcomes in preterm infants (<32 weeks gestation). STUDY DESIGN: Serum 25OHD was measured in mothers and their infants within 24 hours of birth, before the start of enteral vitamin D supplementation, and at discharge from the neonatal intensive care unit. We evaluated the associations between vitamin D status and various early preterm outcomes. RESULTS: Ninety-four preterm infants and their mothers were included; 92% of the infants had a 25OHD level≤50 nmol/L (20 ng/mL), and 64% had a 25OHD level<30 nmol/L (12 ng/mL). A low 25OHD level (<30 nmol/L) in preterm infants at birth was associated with increased oxygen requirement (P=.008), increased duration of intermittent positive-pressure ventilation during resuscitation at delivery (P=.032), and greater need for assisted ventilation (P=.013). CONCLUSION: We observed a high prevalence of low 25OHD (<30 nmol/L), and found an association between vitamin D status and acute respiratory morbidity in preterm infants after birth.
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