| Literature DB >> 2591971 |
T Nagayoshi1, M G Mattei, E Passage, R Knowlton, M L Chu, J Uitto.
Abstract
Laminin, an integral component of basement membranes, consists of three subunit polypeptides, A, B1, and B2 chains. We have recently isolated cDNAs corresponding to human laminin A chain. These cDNAs were utilized for chromosomal in situ hybridizations to establish the genomic location of the laminin A chain gene. Metaphase chromosomes of PHA-stimulated human peripheral blood leukocytes were examined by in situ hybridization with 3H-labeled cDNAs, and the chromosomes were identified by R-banding (fluorochrome-photolysis-Giemsa method). The results indicated that the human laminin A chain is at locus 18p11.3. Since human laminin B1 and B2 chain genes have been previously mapped to chromosomes 7 and 1, respectively, the results indicate that genes encoding human laminin chains reside in separate chromosomes.Entities:
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Year: 1989 PMID： 2591971 DOI： 10.1016/0888-7543(89)90136-5
Source DB: PubMed Journal: Genomics ISSN： 0888-7543 Impact factor: 5.736