| Literature DB >> 25918898 |
Mingyue Ma1, Shuyin Li1, Huanrong Jin1, Yumin Zhang1, Jia Xu1, Dongmei Chen1, Chen Kuimin1, Zhou Yuan1, Chunling Xiao2.
Abstract
Fine particulate matter (PM2.5) pollution is becoming serious in China. This study aimed to investigate the impact of PM2.5 on DNA damage in Shenyang city. The concentration and composition of PM2.5 in traffic policemen's working sites including fields and indoor offices were obtained. Blood samples of field and office policemen were collected to detect DNA damage by Comet assay. Rats were used to further analyzing the oxidative DNA damage. The average concentration of PM2.5 in exposed group was significantly higher than that in control group. Composition analysis revealed that toxic heavy metal and polycyclic aromatic hydrocarbon substances were main elements of this PM2.5. DNA damage in field policemen was significantly higher than those in non-field group. Moreover, animal studies confirmed the oxidative DNA damage induced by PM2.5. Taken together, high DNA damages are found in the Shenyang traffic policemen and rats exposed to high level of airborne PM2.5.Entities:
Keywords: DNA damage; Fine particulate matter; Oxidative stress; Polycyclic aromatic hydrocarbon
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Year: 2015 PMID： 25918898 DOI： 10.1016/j.scitotenv.2015.04.075
Source DB: PubMed Journal: Sci Total Environ ISSN： 0048-9697 Impact factor: 7.963