Literature DB >> 25917795

Uric Acid Promotes Osteogenic Differentiation and Inhibits Adipogenic Differentiation of Human Bone Mesenchymal Stem Cells.

Hui-Zhang Li1, Zhi Chen2, Cang-Long Hou2, Yi-Xing Tang2, Fei Wang2, Qing-Ge Fu3.   

Abstract

To investigate the effect of uric acid on the osteogenic and adipogenic differentiation of human bone mesenchymal stem cells (hBMSCs). The hBMSCs were isolated from bone marrow of six healthy donors. Cell morphology was observed by microscopy and cell surface markers (CD44 and CD34) of hBMSCs were analyzed by immunofluorescence. Cell morphology and immunofluorescence analysis showed that hBMSCs were successfully isolated from bone marrow. The number of hBMSCs in uric acid groups was higher than that in the control group on day 3, 4, and 5. Alizarin red staining showed that number of calcium nodules in uric acid groups was more than that of the control group. Oil red-O staining showed that the number of red fat vacuoles decreased with the increased concentration of uric acid. In summary, uric acid could promote the proliferation and osteogenic differentiation of hBMSCs while inhibit adipogenic differentiation of hBMSCs.
© 2015 Wiley Periodicals, Inc.

Entities:  

Keywords:  Adipogenesis; Human Bone Mesenchymal Stem Cells; Osteogenesis; Proliferation; Uric Acid

Mesh：

Substances：

Year:  2015        PMID： 25917795     DOI： 10.1002/jbt.21707

Source DB:  PubMed          Journal:  J Biochem Mol Toxicol        ISSN： 1095-6670            Impact factor:   3.642


  6 in total

1.  Positive association between serum uric acid and bone mineral density in Chinese type 2 diabetes mellitus stratified by gender and BMI.

Authors:  Mingxin Xu; Junlei Su; Jie Hao; Ni Zhong; Zhiyin Zhang; Ran Cui; Feng Li; Chunjun Sheng; Ge Zhang; Hui Sheng; Shen Qu
Journal:  J Bone Miner Metab       Date:  2017-11-09       Impact factor: 2.626

2.  Association of serum uric acid levels with osteoporosis and bone turnover markers in a Chinese population.

Authors:  Dan-Dan Yan; Jie Wang; Xu-Hong Hou; Yu-Qian Bao; Zhen-Lin Zhang; Cheng Hu; Wei-Ping Jia
Journal:  Acta Pharmacol Sin       Date:  2017-12-14       Impact factor: 6.150

3.  Increased Glycemic Variability Evaluated by Continuous Glucose Monitoring is Associated with Osteoporosis in Type 2 Diabetic Patients.

Authors:  Rong Huang; Huiying Wang; Ziyang Shen; Tingting Cai; Yunting Zhou; Yuming Wang; Wenqing Xia; Bo Ding; Rengna Yan; Huiqin Li; Jindan Wu; Jianhua Ma
Journal:  Front Endocrinol (Lausanne)       Date:  2022-06-06       Impact factor: 6.055

4.  Relationship of Bone Turnover Markers with Serum Uric Acid-to-Creatinine Ratio in Men and Postmenopausal Women with Type 2 Diabetes.

Authors:  Yuling Xing; Jing Liu; Huanxin Liu; Huijuan Ma
Journal:  Diabetes Metab Syndr Obes       Date:  2022-10-19       Impact factor: 3.249

5.  Knee subchondral bone perfusion and its relationship to marrow fat and trabeculation on multi-parametric MRI and micro-CT in experimental CKD.

Authors:  Chao-Ying Wang; Yu-Juei Hsu; Yi-Jen Peng; Herng-Sheng Lee; Yue-Cune Chang; Chih-Shan Chang; Shih-Wei Chiang; Yi-Chih Hsu; Ming-Huang Lin; Guo-Shu Huang
Journal:  Sci Rep       Date:  2017-06-08       Impact factor: 4.379

6.  Serum Uric Acid Level Is Positively Associated With Higher Bone Mineral Density at Multiple Skeletal Sites Among Healthy Qataris.

Authors:  Wisam Nabeel Ibrahim; Nadin Younes; Zumin Shi; Marawan Abdelhamid Abu-Madi
Journal:  Front Endocrinol (Lausanne)       Date:  2021-03-31       Impact factor: 5.555
  6 in total

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