BACKGROUND: There is increasing need to expand availability of donor liver grafts, including steatotic livers. Steatotic liver is associated with poor outcome post-transplantation but with conflicting results in the literature. The aim of this systematic review was to evaluate the impact of steatotic livers on liver transplantation outcomes. METHODS: An electronic search of OVID Medline and Embase databases was performed to identify clinical studies that reported outcomes of steatotic livers in liver transplantation. Data were extracted, and basic descriptive statistics were used to summarise data pooled from individual clinical studies. RESULTS: Ninety-two articles were identified, of which 34 met the inclusion criteria, and stratified analysis were performed. There was a lack of standardised definition of primary non-function or impaired primary function amongst the studies and description of type of steatosis. Severely (>60%) steatotic grafts are associated with increased risk of poor graft function, whilst moderate-severe (>30%) steatotic grafts are associated with decreased graft survival. CONCLUSIONS: Available evidence showed increased risk of poor graft outcome in moderate-severe steatotic livers. A large prospective multi-centred trial will be required to identify the true risks of steatotic livers. Consistent definition of primary non-function/impaired primary function and description of type of steatosis is also required.
BACKGROUND: There is increasing need to expand availability of donor liver grafts, including steatotic livers. Steatotic liver is associated with poor outcome post-transplantation but with conflicting results in the literature. The aim of this systematic review was to evaluate the impact of steatotic livers on liver transplantation outcomes. METHODS: An electronic search of OVID Medline and Embase databases was performed to identify clinical studies that reported outcomes of steatotic livers in liver transplantation. Data were extracted, and basic descriptive statistics were used to summarise data pooled from individual clinical studies. RESULTS: Ninety-two articles were identified, of which 34 met the inclusion criteria, and stratified analysis were performed. There was a lack of standardised definition of primary non-function or impaired primary function amongst the studies and description of type of steatosis. Severely (>60%) steatotic grafts are associated with increased risk of poor graft function, whilst moderate-severe (>30%) steatotic grafts are associated with decreased graft survival. CONCLUSIONS: Available evidence showed increased risk of poor graft outcome in moderate-severe steatotic livers. A large prospective multi-centred trial will be required to identify the true risks of steatotic livers. Consistent definition of primary non-function/impaired primary function and description of type of steatosis is also required.
Authors: Jan P Deroose; Geert Kazemier; Pieter Zondervan; Jan N M Ijzermans; Herold J Metselaar; Ian P J Alwayn Journal: HPB (Oxford) Date: 2011-04-07 Impact factor: 3.647
Authors: Austin L Spitzer; Oliver B Lao; André A S Dick; Ramasamy Bakthavatsalam; Jeffrey B Halldorson; Matthew M Yeh; Melissa P Upton; Jorge D Reyes; James D Perkins Journal: Liver Transpl Date: 2010-07 Impact factor: 5.799
Authors: J Busquets; J Figueras; T Serrano; J Torras; E Ramos; A Rafecas; J Fabregat; C Lama; X Xiol; C Baliellas; E Jaurrieta Journal: Liver Transpl Date: 2001-05 Impact factor: 5.799
Authors: B H Ferraz-Neto; M P V C Zurstrassen; R Hidalgo; L E P Fonseca; T D B Motta; F L Pandullo; M B Rezende; S P Meira-Filho; J R Sá; R C Afonso Journal: Transplant Proc Date: 2007-10 Impact factor: 1.066
Authors: R J Ploeg; A M D'Alessandro; S J Knechtle; M D Stegall; J D Pirsch; R M Hoffmann; T Sasaki; H W Sollinger; F O Belzer; M Kalayoglu Journal: Transplantation Date: 1993-04 Impact factor: 4.939
Authors: S Nikeghbalian; S M R Nejatollahi; H Salahi; A Bahador; B Sabet; H Jalaeian; B Geramizadeh; S M Dehghani; S A Malek-Hosseini Journal: Transplant Proc Date: 2007-05 Impact factor: 1.066
Authors: Dana Tomescu; Mihai Popescu; Lavinia Jipa; Ruxandra Fota; Daniela Ungureanu; Radu Zamfir; Carmen Orban; Simona Olimpia Dima; Irinel Popescu Journal: Rom J Anaesth Intensive Care Date: 2016-04
Authors: Ajay C Donepudi; Gregory J Smith; Oladimeji Aladelokun; Yoojin Lee; Steven J Toro; Marisa Pfohl; Angela L Slitt; Li Wang; Ji-Young Lee; John D Schuetz; José E Manautou Journal: Toxicol Sci Date: 2020-06-01 Impact factor: 4.849
Authors: Kai Roman Laukamp; Simon Lennartz; Vivian Ho; Nils Große Hokamp; David Zopfs; Amit Gupta; Frank Philipp Graner; Jan Borggrefe; Robert Gilkeson; Nikhil Ramaiya Journal: Br J Radiol Date: 2020-01-02 Impact factor: 3.039