Literature DB >> 25916996

HIV-associated Neurocognitive Disorders and Antiretroviral Therapy: Current Concepts and Controversies.

Mark R Etherton1, Jennifer L Lyons, Kevin L Ard.   

Abstract

Antiretroviral drugs may help prevent neurological decline in individuals with HIV infection by suppressing viral replication and associated chronic immune activation in the central nervous system. However, HIV control in the brain may come at the price of drug-induced neurotoxicity. Herein, we review recent advances in the balance between adequate viral suppression in the nervous system and adverse effects of the medications used in HIV treatment.

Entities:  

Year:  2015        PMID： 25916996     DOI： 10.1007/s11908-015-0485-6

Source DB:  PubMed          Journal:  Curr Infect Dis Rep        ISSN： 1523-3847            Impact factor:   3.725


  45 in total

1.  Emtricitabine intolerance in treatment-experienced patients switched from lamivudine: a method of assessing toxicity.

Authors:  Katrina Pollock; Justin Stebbing; Mark Bower; Brian Gazzard; Mark Nelson
Journal:  J Antimicrob Chemother       Date:  2006-05-09       Impact factor: 5.790

2.  Severe insomnia related to high concentrations of raltegravir.

Authors:  Céline Eiden; Hélène Peyriere; Gilles Peytavin; Jacques Reynes
Journal:  AIDS       Date:  2011-03-13       Impact factor: 4.177

3.  Antiretroviral neurotoxicity.

Authors:  Kevin Robertson; Jeff Liner; Rick B Meeker
Journal:  J Neurovirol       Date:  2012-07-19       Impact factor: 2.643

4.  Low cerebrospinal fluid concentrations of the nucleotide HIV reverse transcriptase inhibitor, tenofovir.

Authors:  Brookie M Best; Scott L Letendre; Peter Koopmans; Steven S Rossi; David B Clifford; Ann C Collier; Benjamin B Gelman; Christina M Marra; Justin C McArthur; J Allen McCutchan; Susan Morgello; David M Simpson; Edmund V Capparelli; Ronald J Ellis; Igor Grant
Journal:  J Acquir Immune Defic Syndr       Date:  2012-04-01       Impact factor: 3.731

5.  Randomized trial of central nervous system-targeted antiretrovirals for HIV-associated neurocognitive disorder.

Authors:  Ronald J Ellis; Scott Letendre; Florin Vaida; Richard Haubrich; Robert K Heaton; Ned Sacktor; David B Clifford; Brookie M Best; Susanne May; Anya Umlauf; Mariana Cherner; Chelsea Sanders; Craig Ballard; David M Simpson; Cheryl Jay; J Allen McCutchan
Journal:  Clin Infect Dis       Date:  2013-12-18       Impact factor: 9.079

6.  Protein-free efavirenz concentrations in cerebrospinal fluid and blood plasma are equivalent: applying the law of mass action to predict protein-free drug concentration.

Authors:  L B Avery; N Sacktor; J C McArthur; C W Hendrix
Journal:  Antimicrob Agents Chemother       Date:  2013-01-07       Impact factor: 5.191

7.  Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz.

Authors:  Luis B Tovar-y-Romo; Namandjé N Bumpus; Daniel Pomerantz; Lindsay B Avery; Ned Sacktor; Justin C McArthur; Norman J Haughey
Journal:  J Pharmacol Exp Ther       Date:  2012-09-13       Impact factor: 4.030

8.  Validation of the CNS Penetration-Effectiveness rank for quantifying antiretroviral penetration into the central nervous system.

Authors:  Scott Letendre; Jennifer Marquie-Beck; Edmund Capparelli; Brookie Best; David Clifford; Ann C Collier; Benjamin B Gelman; Justin C McArthur; J Allen McCutchan; Susan Morgello; David Simpson; Igor Grant; Ronald J Ellis
Journal:  Arch Neurol       Date:  2008-01

9.  Discordance between cerebral spinal fluid and plasma HIV replication in patients with neurological symptoms who are receiving suppressive antiretroviral therapy.

Authors:  Ana Canestri; François-Xavier Lescure; Stephane Jaureguiberry; Antoine Moulignier; Corinne Amiel; Anne Geneviève Marcelin; Gilles Peytavin; Roland Tubiana; Gilles Pialoux; Christine Katlama
Journal:  Clin Infect Dis       Date:  2010-03-01       Impact factor: 9.079

10.  Antiretroviral therapy CNS penetration and HIV-1-associated CNS disease.

Authors:  L Garvey; A Winston; J Walsh; F Post; K Porter; B Gazzard; M Fisher; C Leen; D Pillay; T Hill; M Johnson; R Gilson; J Anderson; P Easterbrook; L Bansi; C Orkin; J Ainsworth; A Palfreeman; M Gompels; A N Phillips; C A Sabin
Journal:  Neurology       Date:  2011-02-22       Impact factor: 9.910
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  12 in total

Review 1.  Of mice and monkeys: can animal models be utilized to study neurological consequences of pediatric HIV-1 infection?

Authors:  Heather Carryl; Melanie Swang; Jerome Lawrence; Kimberly Curtis; Herman Kamboj; Koen K A Van Rompay; Kristina De Paris; Mark W Burke
Journal:  ACS Chem Neurosci       Date:  2015-06-19       Impact factor: 4.418

Review 2.  HIV/neuroAIDS biomarkers.

Authors:  Pejman Rahimian; Johnny J He
Journal:  Prog Neurobiol       Date:  2016-04-12       Impact factor: 11.685

Review 3.  HIV-associated neurocognitive disorder--pathogenesis and prospects for treatment.

Authors:  Deanna Saylor; Alex M Dickens; Ned Sacktor; Norman Haughey; Barbara Slusher; Mikhail Pletnikov; Joseph L Mankowski; Amanda Brown; David J Volsky; Justin C McArthur
Journal:  Nat Rev Neurol       Date:  2016-03-11       Impact factor: 42.937

Review 4.  Applications of Brain Organoids for Infectious Diseases.

Authors:  Wenqiang Fan; Kimberly M Christian; Hongjun Song; Guo-Li Ming
Journal:  J Mol Biol       Date:  2021-09-15       Impact factor: 5.469

Review 5.  HIV-1 and Compromised Adult Neurogenesis: Emerging Evidence for a New Paradigm of HAND Persistence

Authors:  Raj Putatunda; Wen-Zhe Ho; Wenhui Hu
Journal:  AIDS Rev       Date:  2019       Impact factor: 2.500

Review 6.  Evaluating Neurodevelopmental Consequences of Perinatal Exposure to Antiretroviral Drugs: Current Challenges and New Approaches.

Authors:  Jordan G Schnoll; Brian Temsamrit; Daniel Zhang; Hongjun Song; Guo-Li Ming; Kimberly M Christian
Journal:  J Neuroimmune Pharmacol       Date:  2019-09-11       Impact factor: 4.147

7.  Prevalence of HIV Associated Neurocognitive Deficit among HIV Positive People in Ethiopia: A Cross Sectional Study at Ayder Referral Hospital.

Authors:  Tilahun Belete; Girmaw Medfu; Ephrem Yemiyamrew
Journal:  Ethiop J Health Sci       Date:  2017-01

Review 8.  Antiretroviral Treatment in HIV-1-Positive Mothers: Neurological Implications in Virus-Free Children.

Authors:  Antonio Victor Campos Coelho; Paola Maura Tricarico; Fulvio Celsi; Sergio Crovella
Journal:  Int J Mol Sci       Date:  2017-02-15       Impact factor: 5.923

9.  Is Tobacco Use Associated with Neurocognitive Dysfunction in Individuals with HIV?

Authors:  Billy Tsima; Sarah Jane Ratcliffe; Robert Schnoll; Ian Frank; Dennis Larry Kolson; Robert Gross
Journal:  J Int Assoc Provid AIDS Care       Date:  2018 Jan-Dec

10.  Neuroprotective effects of the immunomodulatory drug FK506 in a model of HIV1-gp120 neurotoxicity.

Authors:  Jerel A Fields; Cassia Overk; Anthony Adame; Jazmin Florio; Michael Mante; Andrea Pineda; Paula Desplats; Edward Rockenstein; Cristian Achim; Eliezer Masliah
Journal:  J Neuroinflammation       Date:  2016-05-24       Impact factor: 8.322
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