AIMS: The extent of variation attributable to regional differences for the efficacy of brief intervention (BI) to reduce hazardous and harmful alcohol consumption is unclear. The primary aim of this study was to determine overall efficacy of BI at 6- and 12-month follow-up in primary health care (PHC) and emergency department (ED) studies. The secondary aim was to examine whether variance in study outcome can be explained by the geographical region in which trials have taken place (European versus non-European). METHODS: A systematic review and meta-analysis of randomized controlled trials (RCTs) published before August 2014 was undertaken. Twenty RCTs conducted in PHC settings with a total of 8226 participants (European = 4564/non-European = 3662) and eight RCTs conducted in ED settings with a total of 4799 participants (European = 2465/non-European = 2334) were eligible. Primary outcome measure was reduction in grams of alcohol consumed per week for BI and control groups at 6- and 12-month follow-up. An inverse variance model was applied to measure the effect of treatment in mean differences for BI and control groups at 6- and 12-month follow-up. Variance between study outcomes was explored using subgroup analysis of European versus non-European countries. RESULTS: For PHC trials at 6-month follow-up, statistically significant benefits of BI were indicated [mean difference (MD) = -21.98 g/week; 95% confidence interval (CI) = -37.40 to -6.57; P = 0.005]. At 12-month follow-up, statistically significant benefit of BI was evident (MD = -30.86 g/week; 95% CI = -46.49 to -15.23; P = 0.0001). For ED trials at 6-month follow-up, statistically significant benefits of BI were indicated (MD = -17.97 g/week; 95% CI = -29.69 to -6.24; P = .003). At 12-month follow-up, statistically significant benefit in favour of BI was evident (MD = -18.21 g/week; 95% CI = -26.71 to -9.70; P < 0.0001). No statistically significant differences were detected in subgroup analyses of outcomes for European versus non-European studies. CONCLUSIONS: Brief intervention (BI) to reduce alcohol consumption is associated with reducing grams of alcohol consumed per week among hazardous and harmful drinkers at 6- and 12-month follow-up in primary health care and emergency department trials. The geographical region in which trials are undertaken does not appear to explain the variance in trial outcomes for reducing alcohol consumption.
AIMS: The extent of variation attributable to regional differences for the efficacy of brief intervention (BI) to reduce hazardous and harmful alcohol consumption is unclear. The primary aim of this study was to determine overall efficacy of BI at 6- and 12-month follow-up in primary health care (PHC) and emergency department (ED) studies. The secondary aim was to examine whether variance in study outcome can be explained by the geographical region in which trials have taken place (European versus non-European). METHODS: A systematic review and meta-analysis of randomized controlled trials (RCTs) published before August 2014 was undertaken. Twenty RCTs conducted in PHC settings with a total of 8226 participants (European = 4564/non-European = 3662) and eight RCTs conducted in ED settings with a total of 4799 participants (European = 2465/non-European = 2334) were eligible. Primary outcome measure was reduction in grams of alcohol consumed per week for BI and control groups at 6- and 12-month follow-up. An inverse variance model was applied to measure the effect of treatment in mean differences for BI and control groups at 6- and 12-month follow-up. Variance between study outcomes was explored using subgroup analysis of European versus non-European countries. RESULTS: For PHC trials at 6-month follow-up, statistically significant benefits of BI were indicated [mean difference (MD) = -21.98 g/week; 95% confidence interval (CI) = -37.40 to -6.57; P = 0.005]. At 12-month follow-up, statistically significant benefit of BI was evident (MD = -30.86 g/week; 95% CI = -46.49 to -15.23; P = 0.0001). For ED trials at 6-month follow-up, statistically significant benefits of BI were indicated (MD = -17.97 g/week; 95% CI = -29.69 to -6.24; P = .003). At 12-month follow-up, statistically significant benefit in favour of BI was evident (MD = -18.21 g/week; 95% CI = -26.71 to -9.70; P < 0.0001). No statistically significant differences were detected in subgroup analyses of outcomes for European versus non-European studies. CONCLUSIONS: Brief intervention (BI) to reduce alcohol consumption is associated with reducing grams of alcohol consumed per week among hazardous and harmful drinkers at 6- and 12-month follow-up in primary health care and emergency department trials. The geographical region in which trials are undertaken does not appear to explain the variance in trial outcomes for reducing alcohol consumption.
Authors: Erica N Grodin; Lara A Ray; James MacKillop; Aaron C Lim; Mitchell P Karno Journal: Alcohol Clin Exp Res Date: 2019-01-20 Impact factor: 3.455
Authors: Alan K Davis; Brooke J Arterberry; Erin E Bonar; Stephen T Chermack; Frederic C Blow; Rebecca M Cunningham; Maureen A Walton Journal: Drug Alcohol Depend Date: 2018-05-05 Impact factor: 4.492
Authors: Fiona L Hamilton; Jo Hornby; Jessica Sheringham; Stuart Linke; Charlotte Ashton; Kevin Moore; Fiona Stevenson; Elizabeth Murray Journal: Pilot Feasibility Stud Date: 2018-06-15
Authors: Fiona L Hamilton; Jo Hornby; Jessica Sheringham; Stuart Linke; Charlotte Ashton; Kevin Moore; Fiona Stevenson; Elizabeth Murray Journal: Pilot Feasibility Stud Date: 2017-08-21
Authors: Heleen Riper; Adriaan Hoogendoorn; Pim Cuijpers; Eirini Karyotaki; Nikolaos Boumparis; Adriana Mira; Gerhard Andersson; Anne H Berman; Nicolas Bertholet; Gallus Bischof; Matthijs Blankers; Brigitte Boon; Leif Boß; Håvar Brendryen; John Cunningham; David Ebert; Anders Hansen; Reid Hester; Zarnie Khadjesari; Jeannet Kramer; Elizabeth Murray; Marloes Postel; Daniela Schulz; Kristina Sinadinovic; Brian Suffoletto; Christopher Sundström; Hein de Vries; Paul Wallace; Reinout W Wiers; Johannes H Smit Journal: PLoS Med Date: 2018-12-18 Impact factor: 11.069