| Literature DB >> 25916958 |
Lucia L Senin1, Omar Al-Massadi2, Silvia Barja-Fernandez3, Cintia Folgueira4, Cecilia Castelao1, Sulay A Tovar2, Rosaura Leis5, Francisca Lago6, Javier Baltar7, Ivan Baamonde7, Carlos Dieguez2, Felipe F Casanueva8, Luisa M Seoane9.
Abstract
Nesfatin-1, which is derived from the NEFA/nucleobindin 2 (NUCB2) precursor, was recently identified as an anorexigenic peptide that is produced in several tissues including the hypothalamus. Currently, no data exist regarding the regulation of NUCB2/nesfatin-1 production in peripheral tissues, such as gastric mucosa and adipose tissue, through different periods of development. The aim of the present work was to study the variations on circulating levels, mRNA expression and tissue content in gastric mucosa and adipose tissue of NUCB2/nesfatin-1 with age and specially in two clue periods of maturation, weaning and puberty. The weaning period affected NUCB2/nesfatin-1 production in gastric tissue. The testosterone changes associated with the initiation of puberty regulated NUCB2/nesfatin-1 production via adipose tissue and gastric NUCB2/nesfatin-1 production. In conclusion, the production of NUCB2/nesfatin-1 by the stomach and adipose tissue fluctuates with age to regulate energy homeostasis during different states of development.Entities:
Keywords: Adipose tissue; Breastfeeding and puberty; NUCB2/nesfatin-1; Sex; Stomach
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Year: 2015 PMID： 25916958 DOI： 10.1016/j.mce.2015.04.016
Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102