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Literature DB >> 25916826

SHP2: a new target for pro-senescence cancer therapies.

Manuel Serrano¹.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2015 PMID： 25916826 PMCID： PMC4474521 DOI： 10.15252/embj.201591616

Source DB: PubMed Journal: EMBO J ISSN： 0261-4189 Impact factor: 11.598

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10 in total

1. Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity.

Authors: Alberto Toso; Ajinkya Revandkar; Diletta Di Mitri; Ilaria Guccini; Michele Proietti; Manuela Sarti; Sandra Pinton; Jiangwen Zhang; Madhuri Kalathur; Gianluca Civenni; David Jarrossay; Erica Montani; Camilla Marini; Ramon Garcia-Escudero; Eugenio Scanziani; Fabio Grassi; Pier Paolo Pandolfi; Carlo V Catapano; Andrea Alimonti
Journal: Cell Rep Date: 2014-09-25 Impact factor: 9.423

Review 2. Cellular senescence: from physiology to pathology.

Authors: Daniel Muñoz-Espín; Manuel Serrano
Journal: Nat Rev Mol Cell Biol Date: 2014-07 Impact factor: 94.444

Review 3. MDM2-p53 interaction in paediatric solid tumours: preclinical rationale, biomarkers and resistance.

Authors: Giuseppe Barone; Deborah A Tweddle; Jason M Shohet; Louis Chesler; Lucas Moreno; Andrew D J Pearson; Tom Van Maerken
Journal: Curr Drug Targets Date: 2014-01 Impact factor: 3.465

Review 4. Molecular pathways: CDK4 inhibitors for cancer therapy.

Authors: Mark A Dickson
Journal: Clin Cancer Res Date: 2014-05-02 Impact factor: 12.531

5. Shp2 signaling suppresses senescence in PyMT-induced mammary gland cancer in mice.

Authors: Linxiang Lan; Jane D Holland; Jingjing Qi; Stefanie Grosskopf; Jörg Rademann; Regina Vogel; Balázs Györffy; Annika Wulf-Goldenberg; Walter Birchmeier
Journal: EMBO J Date: 2015-03-03 Impact factor: 11.598

6. An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA.

Authors: Marco Demaria; Naoko Ohtani; Sameh A Youssef; Francis Rodier; Wendy Toussaint; James R Mitchell; Remi-Martin Laberge; Jan Vijg; Harry Van Steeg; Martijn E T Dollé; Jan H J Hoeijmakers; Alain de Bruin; Eiji Hara; Judith Campisi
Journal: Dev Cell Date: 2014-12-11 Impact factor: 12.270

7. SHP2 is up-regulated in breast cancer cells and in infiltrating ductal carcinoma of the breast, implying its involvement in breast oncogenesis.

Authors: X Zhou; J Coad; B Ducatman; Y M Agazie
Journal: Histopathology Date: 2008-07-15 Impact factor: 5.087

8. Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.

Authors: Nicola Aceto; Nina Sausgruber; Heike Brinkhaus; Dimos Gaidatzis; Georg Martiny-Baron; Giovanni Mazzarol; Stefano Confalonieri; Micaela Quarto; Guang Hu; Piotr J Balwierz; Mikhail Pachkov; Stephen J Elledge; Erik van Nimwegen; Michael B Stadler; Mohamed Bentires-Alj
Journal: Nat Med Date: 2012-03-04 Impact factor: 53.440

Review 9. Targeting protein tyrosine phosphatase SHP2 for therapeutic intervention.

Authors: Sam Butterworth; Michael Overduin; Alastair J Barr
Journal: Future Med Chem Date: 2014 Impact factor: 3.808

10. Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor.

Authors: Jun Li; Yujia Kang; Longgang Wei; Wenjie Liu; Yingpu Tian; Baozhen Chen; Xiandong Lin; Yang Li; Gen-Sheng Feng; Zhongxian Lu
Journal: PLoS One Date: 2014-07-21 Impact factor: 3.240