Literature DB >> 25916350

HIV-1 subtypes and drug resistance profiles in a cohort of heterosexual patients in Istanbul, Turkey.

Muammer Osman Köksal1, Hayati Beka, Nadine Lübke, Jens Verheyen, Haluk Eraksoy, Atahan Cagatay, Rolf Kaiser, Baki Akgül, Ali Agacfidan.   

Abstract

Turkey is seeing a steady rise in rates of HIV infection in the country. The number of individuals with HIV/AIDS was greater than 7000 in 2014 according to data released by the Ministry of Health, and heterosexual contacts were reported to be the main transmission routes. Istanbul has the highest number of reported cases of HIV infection. The aim of the study was to determine the prevalence of HIV-1 drug resistance in 50 heterosexual patients from Istanbul. The most prevalent subtype was found to be subtype B (56.2 %). Resistance-associated mutations were found in 14 patients with 6/14 patients being therapy-experienced and 8/14 therapy naive at the time point of analysis. With increasing number of patients who require treatment and the rapid up-scaling of the antiretroviral therapy in Turkey, HIV-1 drug resistance testing is recommended before starting treatment in order to achieve better clinical outcomes.

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Year:  2015        PMID： 25916350     DOI： 10.1007/s00430-015-0419-9

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  36 in total

1.  Prevalence of the mutational pattern E44D/A and/or V118I in the reverse transcriptase (RT) gene of HIV-1 in relation to treatment with nucleoside analogue RT inhibitors.

Authors:  Brigitte Montes; Michel Segondy
Journal:  J Med Virol       Date:  2002-03       Impact factor: 2.327

2.  Mutational patterns in the frameshift-regulating site of HIV-1 selected by protease inhibitors.

Authors:  Elena Knops; Léa Brakier-Gingras; Eugen Schülter; Herbert Pfister; Rolf Kaiser; Jens Verheyen
Journal:  Med Microbiol Immunol       Date:  2011-12-27       Impact factor: 3.402

3.  Prediction of HIV-1 drug susceptibility phenotype from the viral genotype using linear regression modeling.

Authors:  H Vermeiren; E Van Craenenbroeck; P Alen; L Bacheler; G Picchio; P Lecocq
Journal:  J Virol Methods       Date:  2007-06-15       Impact factor: 2.014

4.  Determination of drug resistance and virus typology in HIV-1-positive pediatric patients in Istanbul, Turkey.

Authors:  Ozlem Yoldaş; Ali Ağaçfidan; Nadine Lübke; Ayper Somer; Selda Hançerli; Jens Verheyen; Rolf Kaiser; Baki Akgül
Journal:  Intervirology       Date:  2014-06-28       Impact factor: 1.763

5.  Compensatory mutations at the HIV cleavage sites p7/p1 and p1/p6-gag in therapy-naive and therapy-experienced patients.

Authors:  Jens Verheyen; Elena Litau; Tobias Sing; Martin Däumer; Melanie Balduin; Mark Oette; Gerd Fätkenheuer; Jürgen K Rockstroh; Ulrike Schuldenzucker; Daniel Hoffmann; Herbert Pfister; Rolf Kaiser
Journal:  Antivir Ther       Date:  2006

6.  Primary HIV drug resistance and efficacy of first-line antiretroviral therapy guided by resistance testing.

Authors:  Mark Oette; Rolf Kaiser; Martin Däumer; Ruth Petch; Gerd Fätkenheuer; Horst Carls; Jürgen Kurt Rockstroh; Dirk Schmalöer; Jürgen Stechel; Torsten Feldt; Herbert Pfister; Dieter Häussinger
Journal:  J Acquir Immune Defic Syndr       Date:  2006-04-15       Impact factor: 3.731

7.  Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing.

Authors:  Soo-Yon Rhee; Tommy Liu; Jaideep Ravela; Matthew J Gonzales; Robert W Shafer
Journal:  Antimicrob Agents Chemother       Date:  2004-08       Impact factor: 5.191

8.  [Molecular Epidemiological Analysis of HIV-1 pol Gene Sequences Isolated in Istanbul, Turkey].

Authors:  Murat Sayan; Hayat Kumbasar Karaosmanoğlu; Birgül Mete; Alper Gündüz; Ozlem Aydın; Mücahit Yemişen; Nuriye Uzun; Fehmi Tabak
Journal:  Mikrobiyol Bul       Date:  2013-01       Impact factor: 0.622

9.  Human immunodeficiency virus reverse transcriptase and protease sequence database.

Authors:  Soo-Yon Rhee; Matthew J Gonzales; Rami Kantor; Bradley J Betts; Jaideep Ravela; Robert W Shafer
Journal:  Nucleic Acids Res       Date:  2003-01-01       Impact factor: 16.971

10.  HIV-1 Gag C-terminal amino acid substitutions emerging under selective pressure of protease inhibitors in patient populations infected with different HIV-1 subtypes.

Authors:  Guangdi Li; Jens Verheyen; Kristof Theys; Supinya Piampongsant; Kristel Van Laethem; Anne-Mieke Vandamme
Journal:  Retrovirology       Date:  2014-09-25       Impact factor: 4.602
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  2 in total

1.  HIV-1 replication in central nervous system increases over time on only protease inhibitor therapy.

Authors:  Maximilian Donath; Timo Wolf; Martin Stürmer; Eva Herrmann; Markus Bickel; Pavel Khaykin; Siri Göpel; Peter Gute; Annette Haberl; Philipp de Leuw; Gundolf Schüttfort; Annemarie Berger; Christoph Stephan
Journal:  Med Microbiol Immunol       Date:  2016-07-28       Impact factor: 3.402

2.  Prevalence of K65R in patients treated with tenofovir disoproxil fumarate: recommendations based on the Frankfurt HIV Cohort Study Resistance Database (FHCS-RD).

Authors:  Claudia Reinheimer; Anna Wesner; Oliver T Keppler; Hans Wilhelm Doerr; Eva Herrmann; Martin Stürmer; Christoph Stephan
Journal:  Med Microbiol Immunol       Date:  2016-01-08       Impact factor: 3.402
  2 in total

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