Large corneal grafts can be successful.

Seventeen grafts of 10 mm in diameter or larger have been performed on 16 eyes of 15 patients. The major indications for surgery were infections or perforations or both. Follow-up has ranged from 8-54 months (mean 26.4). The 4 year survival probability was 0.64. Although the procedure was successful in saving all but one eye and restored useful vision in the majority, complications including cataract, glaucoma, graft rejection episodes and infections were encountered. The management of these complications is described. At final review, 13 eyes had clear grafts including those in whom regraft had been performed. These results have only been achieved by close co-operation between patients and the medical team responsible for their care.