Literature DB >> 25915633

HIV-1 and interferons: who's interfering with whom?

Tomas Doyle1, Caroline Goujon1, Michael H Malim1.   

Abstract

The ability of interferons (IFNs) to inhibit HIV-1 replication in cell culture models has long been recognized, and the therapeutic administration of IFNα to HIV-1-infected patients who are not receiving antiretroviral therapy produces a clear but transient decrease in plasma viral load. Conversely, studies of chronic HIV-1 infection in humans and SIV-infected animal models of AIDS show positive correlations between elevated plasma levels of IFNs, increased expression of IFN-stimulated genes (ISGs), biomarkers of inflammation and disease progression. In this Review, we discuss the evidence that IFNs can control HIV-1 replication in vivo and debate the controversial role of IFNs in promoting the pathological sequelae of chronic HIV-1 infection.

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Year:  2015        PMID： 25915633      PMCID： PMC7768976          DOI： 10.1038/nrmicro3449

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  114 in total

Review 1.  Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.

Authors:  Frank Kirchhoff
Journal:  Cell Host Microbe       Date:  2010-07-22       Impact factor: 21.023

Review 2.  Interferon signalling network in innate defence.

Authors:  Akinori Takaoka; Hideyuki Yanai
Journal:  Cell Microbiol       Date:  2006-06       Impact factor: 3.715

3.  Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection.

Authors:  Gilad Doitsh; Nicole L K Galloway; Xin Geng; Zhiyuan Yang; Kathryn M Monroe; Orlando Zepeda; Peter W Hunt; Hiroyu Hatano; Stefanie Sowinski; Isa Muñoz-Arias; Warner C Greene
Journal:  Nature       Date:  2014-01-23       Impact factor: 49.962

4.  Characterization of the alpha interferon-induced postentry block to HIV-1 infection in primary human macrophages and T cells.

Authors:  Caroline Goujon; Michael H Malim
Journal:  J Virol       Date:  2010-07-07       Impact factor: 5.103

5.  Conserved footprints of APOBEC3G on Hypermutated human immunodeficiency virus type 1 and human endogenous retrovirus HERV-K(HML2) sequences.

Authors:  Andrew E Armitage; Aris Katzourakis; Tulio de Oliveira; John J Welch; Robert Belshaw; Kate N Bishop; Beatrice Kramer; Andrew J McMichael; Andrew Rambaut; Astrid K N Iversen
Journal:  J Virol       Date:  2008-06-18       Impact factor: 5.103

6.  Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response.

Authors:  Béatrice Jacquelin; Véronique Mayau; Brice Targat; Anne-Sophie Liovat; Désirée Kunkel; Gaël Petitjean; Marie-Agnès Dillies; Pierre Roques; Cécile Butor; Guido Silvestri; Luis D Giavedoni; Pierre Lebon; Françoise Barré-Sinoussi; Arndt Benecke; Michaela C Müller-Trutwin
Journal:  J Clin Invest       Date:  2009-12       Impact factor: 14.808

7.  Tetherin inhibits retrovirus release and is antagonized by HIV-1 Vpu.

Authors:  Stuart J D Neil; Trinity Zang; Paul D Bieniasz
Journal:  Nature       Date:  2008-01-16       Impact factor: 49.962

8.  Innate immune responses and rapid control of inflammation in African green monkeys treated or not with interferon-alpha during primary SIVagm infection.

Authors:  Béatrice Jacquelin; Gaël Petitjean; Désirée Kunkel; Anne-Sophie Liovat; Simon P Jochems; Kenneth A Rogers; Mickaël J Ploquin; Yoann Madec; Françoise Barré-Sinoussi; Nathalie Dereuddre-Bosquet; Pierre Lebon; Roger Le Grand; François Villinger; Michaela Müller-Trutwin
Journal:  PLoS Pathog       Date:  2014-07-03       Impact factor: 6.823

Review 9.  Cytosolic sensing of viruses.

Authors:  Delphine Goubau; Safia Deddouche; Caetano Reis e Sousa
Journal:  Immunity       Date:  2013-05-23       Impact factor: 31.745

10.  HIV-1 evades innate immune recognition through specific cofactor recruitment.

Authors:  Mahdad Noursadeghi; Greg J Towers; Jane Rasaiyaah; Choon Ping Tan; Adam J Fletcher; Amanda J Price; Caroline Blondeau; Laura Hilditch; David A Jacques; David L Selwood; Leo C James
Journal:  Nature       Date:  2013-11-06       Impact factor: 49.962
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  140 in total

1.  Interferon epsilon promotes HIV restriction at multiple steps of viral replication.

Authors:  Albert Garcia-Minambres; Sahar G Eid; Niamh E Mangan; Corinna Pade; San S Lim; Antony Y Matthews; Nicole A de Weerd; Paul J Hertzog; Johnson Mak
Journal:  Immunol Cell Biol       Date:  2017-01-03       Impact factor: 5.126

2.  Relative mRNA Expression Levels of Restriction Factors and Antiviral Genes in Fetal and Adult Human Monocytes and Monocyte-Derived Macrophages.

Authors:  Karen Trang; Rui André Raposo; Margaret M Lowe; Elisabeth R Krow-Lucal; Wes Yonemoto; Vinicius D Cabido; Devi SenGupta; Joseph M McCune
Journal:  Viral Immunol       Date:  2017-02-02       Impact factor: 2.257

Review 3.  HIV-1 capsid: the multifaceted key player in HIV-1 infection.

Authors:  Edward M Campbell; Thomas J Hope
Journal:  Nat Rev Microbiol       Date:  2015-08       Impact factor: 60.633

4.  A Novel Phenotype Links HIV-1 Capsid Stability to cGAS-Mediated DNA Sensing.

Authors:  Mohammad Adnan Siddiqui; Akatsuki Saito; Upul D Halambage; Damien Ferhadian; Douglas K Fischer; Ashwanth C Francis; Gregory B Melikyan; Zandrea Ambrose; Christopher Aiken; Masahiro Yamashita
Journal:  J Virol       Date:  2019-07-30       Impact factor: 5.103

5.  TIM-mediated inhibition of HIV-1 release is antagonized by Nef but potentiated by SERINC proteins.

Authors:  Minghua Li; Abdul A Waheed; Jingyou Yu; Cong Zeng; Hui-Yu Chen; Yi-Min Zheng; Amin Feizpour; Björn M Reinhard; Suryaram Gummuluru; Steven Lin; Eric O Freed; Shan-Lu Liu
Journal:  Proc Natl Acad Sci U S A       Date:  2019-03-06       Impact factor: 11.205

Review 6.  Type I interferon signaling, regulation and gene stimulation in chronic virus infection.

Authors:  Sabelo Lukhele; Giselle M Boukhaled; David G Brooks
Journal:  Semin Immunol       Date:  2019-05-30       Impact factor: 11.130

Review 7.  Innate and intrinsic antiviral immunity in Drosophila.

Authors:  Assel Mussabekova; Laurent Daeffler; Jean-Luc Imler
Journal:  Cell Mol Life Sci       Date:  2017-01-19       Impact factor: 9.261

8.  Short-Term Pegylated Interferon α2a Treatment Does Not Significantly Reduce the Viral Reservoir of Simian Immunodeficiency Virus-Infected, Antiretroviral Therapy-Treated Rhesus Macaques.

Authors:  David Palesch; Steven E Bosinger; Maud Mavigner; James M Billingsley; Cameron Mattingly; Diane G Carnathan; Mirko Paiardini; Ann Chahroudi; Thomas H Vanderford; Guido Silvestri
Journal:  J Virol       Date:  2018-06-29       Impact factor: 5.103

9.  Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs.

Authors:  Liang Cheng; Jianping Ma; Jingyun Li; Dan Li; Guangming Li; Feng Li; Qing Zhang; Haisheng Yu; Fumihiko Yasui; Chaobaihui Ye; Li-Chung Tsao; Zhiyuan Hu; Lishan Su; Liguo Zhang
Journal:  J Clin Invest       Date:  2016-12-12       Impact factor: 14.808

10.  IFN-ε protects primary macrophages against HIV infection.

Authors:  Carley Tasker; Selvakumar Subbian; Pan Gao; Jennifer Couret; Carly Levine; Saleena Ghanny; Patricia Soteropoulos; Xilin Zhao; Nathaniel Landau; Wuyuan Lu; Theresa L Chang
Journal:  JCI Insight       Date:  2016-12-08
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