| Literature DB >> 25915436 |
Timothy D Neubert1, Yvonne Schmidt1, Erica Conroy1, Dean Stamos1.
Abstract
A radical mediated C-H functionalization of 3,6-dichloropyridazine using primary alcohols, t-BuOOH, and TiCl3 to access alkoxy pyridazines is described. This transformation is conducted open to air and on gram scale. A subsequent cyclization step can then be employed to efficiently access diversely substituted tetrahydropyridopyridazines with multiple functional handles.Entities:
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Year: 2015 PMID： 25915436 DOI： 10.1021/acs.orglett.5b00861
Source DB: PubMed Journal: Org Lett ISSN： 1523-7052 Impact factor: 6.005