Correction: FOXO4-Knockdown Suppresses Oxidative Stress-Induced Apoptosis of Early Pro-Angiogenic Cells and Augments Their Neovascularization Capacities in Ischemic Limbs.

Following the publication of the article, the following errors were identified in two of the figures:

- The FOXO4 panel Fig 2A was duplicated as the right panel in Fig 2C.

Fig 2

FOXO expressions in apoptotic EPCs.

(A) Representative western blotting photos of expressions of FOXO3a and FOXO4 in EPCs and H2O2-treated-EPCs. EPCs were derived from atherosclerotic patients. (B) Pooled data of the FOXO3a/β-actin and FOXO4/β-actin expression ratios for the cells (*: p<0.005; n = 4–13, each). (C) A representative western blotting photo of expressions of FOXO4 in EPCs and H2O2-treated-EPCs. (D) Pooled data of the FOXO3a/β-actin and FOXO4/β-actin expression ratios of the cells. H-EPCs and P-EPCs indicate healthy volunteer-derived EPCs and atherosclerotic patient-derived EPCs of a different group from figures 2A and B, respectively (*: p<0.05; §: p<0.01; n = 5, each).

- The right panel of Fig 7A incorrectly displays the flip vertical image of the left panel in Fig 7C.

Fig 7

ROS production in athymic nude rat ischemic limbs.

(A) Representative fluorescence microscopic images of DHE-stained tissues of the non-ischemic and ischemic limbs of athymic nude rats. DHE was stained red. Scale bar: 100 μm. (B) Pooled data of DHE fluorescence intensity of the rat non-ischemic and ischemic limbs (*: p<0.05; n = 12, each). (C) Representative fluorescence microscopic images of DHE-stained tissues of the ischemic limbs 24 h after intramuscular injection of PBS, EPCs, or FOXO4KD-EPCs. Scale bar: 100 μm. (D) Pooled data of DHE fluorescence intensity of the ischemic limbs 24 h after intramuscular injection of PBS, EPCs, or FOXO4KD-EPCs (n = 7, each).

The authors apologize for these errors.

Additional experiments have been carried out to assess FOXO4 expression in atherosclerotic patient-derived early pro-angiogenic cells from additional patients with or without H2O2 pretreatment (n = 13), the results from these experiments support the conclusions reported in the article.

The authors are providing a new Fig 2 reporting the results of the replication experiments as well as a corrected Fig 7.

Raw data for revised figures

(ZIP)

Click here for additional data file.