Hong-Qiang Zhao1, He Wu2, Ran Meng2, Shufa Du3, Shu-Juan Tao4. 1. Department of Internal Medicine of Laiwu People's Hospital Branch of Shandong Province, Shandong, China. 2. Department of Endocrinology of Laiwu People's Hospital of Shandong Province, Shandong, China. 3. Department of Nutrition and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. 4. Laiwu Maternal and Child Health Hospital of Shandong Province, Shandong, China.
Abstract
SCOPE: This study examined the associations of serum transferrin and metabolic disorders among Chinese population. METHODS AND RESULTS: This study is based on nation-wide, population-based China Health and Nutrition survey including 8564 men and women aged 18 years or older. Anthropometric and fasting blood glucose, insulin, lipids, and transferrin data were collected. Elevated transferrin concentrations associated with higher body mass index, waist circumference, lipids, insulin, glucose (all p < 0.0001). Serum transferrin concentrations increased gradually with increasing numbers of metabolic syndrome (MetS) components among men and women (p = 0.0003). Elevated concentrations of transferrin were significantly related with higher risk of MetS (p = 0.0006), obesity (p = 0.0089), overweight (p < 0.0001). No associations between transferrin concentrations and risk of diabetes and high blood pressure were observed in both men and women. CONCLUSION: Elevated transferrin concentrations were positively associated with risk of MetS and obesity, but not with risk of diabetes among Chinese.
SCOPE: This study examined the associations of serum transferrin and metabolic disorders among Chinese population. METHODS AND RESULTS: This study is based on nation-wide, population-based China Health and Nutrition survey including 8564 men and women aged 18 years or older. Anthropometric and fasting blood glucose, insulin, lipids, and transferrin data were collected. Elevated transferrin concentrations associated with higher body mass index, waist circumference, lipids, insulin, glucose (all p < 0.0001). Serum transferrin concentrations increased gradually with increasing numbers of metabolic syndrome (MetS) components among men and women (p = 0.0003). Elevated concentrations of transferrin were significantly related with higher risk of MetS (p = 0.0006), obesity (p = 0.0089), overweight (p < 0.0001). No associations between transferrin concentrations and risk of diabetes and high blood pressure were observed in both men and women. CONCLUSION: Elevated transferrin concentrations were positively associated with risk of MetS and obesity, but not with risk of diabetes among Chinese.