OBJECTIVE: Asymmetry in brain structure and function is implicated in the pathogenesis of psychiatric disorders. Although right hemisphere abnormality has been documented in obsessive-compulsive disorder (OCD), cerebral asymmetry is rarely examined. Therefore, in this study, we examined anomalous cerebral asymmetry in OCD patients using the line bisection task. METHODS: A total of 30 patients with OCD and 30 matched healthy controls were examined using a reliable and valid two-hand line bisection (LBS) task. The comparative profiles of LBS scores were analysed using analysis of covariance. RESULTS: Patients with OCD bisected significantly less number of lines to the left and had significant rightward deviation than controls, indicating right hemisphere dysfunction. The correlations observed in this study suggest that those with impaired laterality had more severe illness at baseline. CONCLUSIONS: The findings of this study indicate abnormal cerebral lateralisation and right hemisphere dysfunction in OCD patients.
OBJECTIVE: Asymmetry in brain structure and function is implicated in the pathogenesis of psychiatric disorders. Although right hemisphere abnormality has been documented in obsessive-compulsive disorder (OCD), cerebral asymmetry is rarely examined. Therefore, in this study, we examined anomalous cerebral asymmetry in OCDpatients using the line bisection task. METHODS: A total of 30 patients with OCD and 30 matched healthy controls were examined using a reliable and valid two-hand line bisection (LBS) task. The comparative profiles of LBS scores were analysed using analysis of covariance. RESULTS:Patients with OCD bisected significantly less number of lines to the left and had significant rightward deviation than controls, indicating right hemisphere dysfunction. The correlations observed in this study suggest that those with impaired laterality had more severe illness at baseline. CONCLUSIONS: The findings of this study indicate abnormal cerebral lateralisation and right hemisphere dysfunction in OCDpatients.
Entities:
Keywords:
asymmetry; laterality; line bisection; obsessive–compulsive disorder; right hemisphere
Authors: Xiang-Zhen Kong; Premika S W Boedhoe; Yoshinari Abe; Pino Alonso; Stephanie H Ameis; Paul D Arnold; Francesca Assogna; Justin T Baker; Marcelo C Batistuzzo; Francesco Benedetti; Jan C Beucke; Irene Bollettini; Anushree Bose; Silvia Brem; Brian P Brennan; Jan Buitelaar; Rosa Calvo; Yuqi Cheng; Kang Ik K Cho; Sara Dallaspezia; Damiaan Denys; Benjamin A Ely; Jamie Feusner; Kate D Fitzgerald; Jean-Paul Fouche; Egill A Fridgeirsson; David C Glahn; Patricia Gruner; Deniz A Gürsel; Tobias U Hauser; Yoshiyuki Hirano; Marcelo Q Hoexter; Hao Hu; Chaim Huyser; Anthony James; Fern Jaspers-Fayer; Norbert Kathmann; Christian Kaufmann; Kathrin Koch; Masaru Kuno; Gerd Kvale; Jun Soo Kwon; Luisa Lazaro; Yanni Liu; Christine Lochner; Paulo Marques; Rachel Marsh; Ignacio Martínez-Zalacaín; David Mataix-Cols; Sarah E Medland; José M Menchón; Luciano Minuzzi; Pedro S Moreira; Astrid Morer; Pedro Morgado; Akiko Nakagawa; Takashi Nakamae; Tomohiro Nakao; Janardhanan C Narayanaswamy; Erika L Nurmi; Joseph O'Neill; Jose C Pariente; Chris Perriello; John Piacentini; Fabrizio Piras; Federica Piras; Christopher Pittenger; Y C Janardhan Reddy; Oana Georgiana Rus-Oswald; Yuki Sakai; Joao R Sato; Lianne Schmaal; H Blair Simpson; Noam Soreni; Carles Soriano-Mas; Gianfranco Spalletta; Emily R Stern; Michael C Stevens; S Evelyn Stewart; Philip R Szeszko; David F Tolin; Aki Tsuchiyagaito; Daan van Rooij; Guido A van Wingen; Ganesan Venkatasubramanian; Zhen Wang; Je-Yeon Yun; Paul M Thompson; Dan J Stein; Odile A van den Heuvel; Clyde Francks Journal: Biol Psychiatry Date: 2019-04-30 Impact factor: 13.382
Authors: Xiang-Zhen Kong; Merel C Postema; Tulio Guadalupe; Carolien de Kovel; Premika S W Boedhoe; Martine Hoogman; Samuel R Mathias; Daan van Rooij; Dick Schijven; David C Glahn; Sarah E Medland; Neda Jahanshad; Sophia I Thomopoulos; Jessica A Turner; Jan Buitelaar; Theo G M van Erp; Barbara Franke; Simon E Fisher; Odile A van den Heuvel; Lianne Schmaal; Paul M Thompson; Clyde Francks Journal: Hum Brain Mapp Date: 2020-05-18 Impact factor: 5.038