Shan Lu1, Jianyu Xu1, Xiangying Xu1,2, Songliu Hu1, Bin Li3, Wenxin Li1. 1. Department of Radiation Oncology, The Third Affiliated Hospital of Harbin Medical University, Harbin, China. 2. Institute of Cancer Prevention and Treatment of Heilongjiang Province, Harbin, China. 3. Department of Plastic Surgery, Nanfang Hospital of Southern Medical University, Guangzhou, Guangdong, China.
Abstract
AIMS: To examine the expression of astrocyte elevated gene-1 (AEG-1) in non-small-cell lung cancer (NSCLC) and analyse the correlation between AEG-1 expression and the prognosis of the patients, particularly the relationship between AEG-1 expression and postoperative chemotherapy and radiotherapy. METHODS: The expression of AEG-1 was analysed by immunohistochemistry in 225 primary NSCLC specimens and 42 adjacent normal lung tissue specimens. Statistical analyses were performed to evaluate the correlation between AEG-1 expression and the clinicopathological characteristics of the patients as well as the predictive value of AEG-1. RESULTS: The expression of AEG-1 was associated with the pathological stage (P < 0.001) and lymph node status (P = 0.028). A multivariate analysis indicated that AEG-1 expression was an independent prognostic factor for both overall survival (OS) and disease-free survival (DFS). In the postoperative chemotherapy group, the OS (P = 0.014) and DFS (P = 0.009) in the low AEG-1 expression group were longer than the survival times in the high AEG-1 expression group. In the postoperative radiotherapy group, the local recurrence-free survival was significantly shorter in patients whose tumours showed high AEG-1 expression (P = 0.016). CONCLUSIONS: AEG-1 expression could be a predictor for OS and DFS in NSCLC patients. Patients with low AEG-1 expression received the greatest benefit from both postoperative chemotherapy and radiotherapy.
AIMS: To examine the expression of astrocyte elevated gene-1 (AEG-1) in non-small-cell lung cancer (NSCLC) and analyse the correlation between AEG-1 expression and the prognosis of the patients, particularly the relationship between AEG-1 expression and postoperative chemotherapy and radiotherapy. METHODS: The expression of AEG-1 was analysed by immunohistochemistry in 225 primary NSCLC specimens and 42 adjacent normal lung tissue specimens. Statistical analyses were performed to evaluate the correlation between AEG-1 expression and the clinicopathological characteristics of the patients as well as the predictive value of AEG-1. RESULTS: The expression of AEG-1 was associated with the pathological stage (P < 0.001) and lymph node status (P = 0.028). A multivariate analysis indicated that AEG-1 expression was an independent prognostic factor for both overall survival (OS) and disease-free survival (DFS). In the postoperative chemotherapy group, the OS (P = 0.014) and DFS (P = 0.009) in the low AEG-1 expression group were longer than the survival times in the high AEG-1 expression group. In the postoperative radiotherapy group, the local recurrence-free survival was significantly shorter in patients whose tumours showed high AEG-1 expression (P = 0.016). CONCLUSIONS:AEG-1 expression could be a predictor for OS and DFS in NSCLCpatients. Patients with low AEG-1 expression received the greatest benefit from both postoperative chemotherapy and radiotherapy.
Authors: Dina A Ali; Nesreen M Sabry; Ahmed M Kabel; Rasha A Gaber; Hwaida M Mokhtar; Sara M Samy; Mohamed A Elrashidy; Samir A Salama; Dina Abdelhai Journal: Medicina (Kaunas) Date: 2021-08-24 Impact factor: 2.430