| Literature DB >> 25913116 |
Rossella Fioravanti1, Nicoletta Desideri2, Mariangela Biava2, Paolo Droghini2, Elena Maria Atzori2, Cristina Ibba3, Gabriella Collu3, Giuseppina Sanna3, Ilenia Delogu3, Roberta Loddo4.
Abstract
A series of N-((1,3-diphenyl-1H-pyrazol-4-yl)methyl)anilines were synthesized and evaluated in vitro for cytotoxicity and antiviral activity against a large panel of viruses. Most of the tested compounds interfered with RSV replication in the micromolar concentrations (EC50s ranging from 5 μM to 28 μM). SAR studies suggested that the presence of a trifluoromethyl group in R(1) abolished the anti-RSV activity and enhanced the cytotoxicity while the best results in term of both anti-RSV activity and selectivity were obtained by the introduction in R(1) of a chlorine or a bromine atom.Entities:
Keywords: Aniline derivatives; Anti-RSV activity; Antiviral activity; Pyrazole derivatives; RNA and DNA viruses
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Year: 2015 PMID： 25913116 DOI： 10.1016/j.bmcl.2015.04.006
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823