Liang-Ping Zhao1, Wei-Ting Xu2, Li Wang2, Tao You2, Siew-Pang Chan3, Xin Zhao4, Xiang-Jun Yang5. 1. Department of Cardiology, The First Affiliated Hospital of Soochow University, PR China; Department of Cardiology, The Second Affiliated Hospital of Soochow University, PR China. 2. Department of Cardiology, The Second Affiliated Hospital of Soochow University, PR China. 3. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Republic of Singapore; Cardiovscular Research Institute, National University Heart Centre Singapore, National University Health System, Republic of Singapore; Department of Mathematics & Statistics, Faculty of Science, Technology & Engineering, La Trobe University, Melbourne, Vic, Australia. 4. Department of Cardiology, The First Affiliated Hospital of Soochow University, PR China. 5. Department of Cardiology, The First Affiliated Hospital of Soochow University, PR China. Electronic address: yang_xiangjun57@sina.com.
Abstract
OBJECTIVES: Adropin is a newly identified secreted protein implicated in the regulation of insulin sensitivity and vascular endothelial function. Recent studies have shown that lower serum adropin level is related to acute myocardial infarction and coronary atherosclerosis. The primary objective of this study was to ascertain the association of serum adropin level with stable coronary artery disease (SCAD). METHODS: We prospectively recruited a cohort of patients with SCAD and similar sample size subjects without coronary artery disease as controls. Their serum adropin levels were measured, and the severity of coronary atherosclerosis in SCAD patients was quantified with the syntax score. RESULTS: A total of 116 patients with SCAD and 116 control subjects without coronary artery disease were recruited. Patients with SCAD had lower serum adropin levels when compared with the controls (59.2±19.3 versus 70.0±18.2 pg/mL, P<0.001). The multiple logistic regression revealed that low serum adropin level was a significant predictor of SCAD (AOR 0.976, 95% CI 0.960-0.992; p=0.003). Through the gamma regression model, it was further revealed that serum adropin level is significantly associated with syntax score (coefficient: -0.134, 95% CI: -0.212- -0.056; p=0.001). CONCLUSIONS: Low serum adropin level is a significant predictor of SCAD. It is also associated with syntax score, thus indicating the close relationship between adropin and coronary atherosclerosis.
OBJECTIVES:Adropin is a newly identified secreted protein implicated in the regulation of insulin sensitivity and vascular endothelial function. Recent studies have shown that lower serum adropin level is related to acute myocardial infarction and coronary atherosclerosis. The primary objective of this study was to ascertain the association of serum adropin level with stable coronary artery disease (SCAD). METHODS: We prospectively recruited a cohort of patients with SCAD and similar sample size subjects without coronary artery disease as controls. Their serum adropin levels were measured, and the severity of coronary atherosclerosis in SCAD patients was quantified with the syntax score. RESULTS: A total of 116 patients with SCAD and 116 control subjects without coronary artery disease were recruited. Patients with SCAD had lower serum adropin levels when compared with the controls (59.2±19.3 versus 70.0±18.2 pg/mL, P<0.001). The multiple logistic regression revealed that low serum adropin level was a significant predictor of SCAD (AOR 0.976, 95% CI 0.960-0.992; p=0.003). Through the gamma regression model, it was further revealed that serum adropin level is significantly associated with syntax score (coefficient: -0.134, 95% CI: -0.212- -0.056; p=0.001). CONCLUSIONS: Low serum adropin level is a significant predictor of SCAD. It is also associated with syntax score, thus indicating the close relationship between adropin and coronary atherosclerosis.
Authors: Mehmet Akif Erdol; Seyma Ertem; Ahmet Goktug Ertem; Koray Demirtas; Sefa Unal; Mustafa Karanfil; Ahmet Akdi; Cagri Yayla Journal: Med Princ Pract Date: 2019-07-11 Impact factor: 1.927
Authors: Ana Rita de Oliveira Dos Santos; Bárbara de Oliveira Zanuso; Vitor Fernando Bordin Miola; Sandra Maria Barbalho; Patrícia C Santos Bueno; Uri Adrian Prync Flato; Claudia Rucco P Detregiachi; Daniela Vieira Buchaim; Rogério Leone Buchaim; Ricardo José Tofano; Claudemir Gregório Mendes; Viviane Alessandra Capelluppi Tofano; Jesselina F Dos Santos Haber Journal: Int J Mol Sci Date: 2021-03-05 Impact factor: 5.923