Literature DB >> 2591066

Evidence for a major additive gene in ulcerative colitis.

U Monsén1, L Iselius, C Johansson, G Hellers.   

Abstract

Complex segregation analysis of 124 families with ulcerative colitis with two or more affected individuals suggests a rare additive major gene causing the disease with about 20% affected among the heterozygotes for the gene. There was no evidence for multifactorial inheritance.

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Mesh：

Year:  1989        PMID： 2591066

Source DB:  PubMed          Journal:  Clin Genet        ISSN： 0009-9163            Impact factor:   4.438


  8 in total

1.  Analysis of the contribution of HLA genes to genetic predisposition in inflammatory bowel disease.

Authors:  I Naom; J Lee; D Ford; S J Bowman; J S Lanchbury; I Haris; S V Hodgson; D Easton; J Lennard-Jones; C G Mathew
Journal:  Am J Hum Genet       Date:  1996-07       Impact factor: 11.025

2.  P-ANCA in monozygotic twins with inflammatory bowel disease.

Authors:  P Yang; G Järnerot; D Danielsson; C Tysk; E Lindberg
Journal:  Gut       Date:  1995-06       Impact factor: 23.059

Review 3.  Crohn's disease: ancient and modern.

Authors:  M S Smith; A J Wakefield
Journal:  Postgrad Med J       Date:  1994-03       Impact factor: 2.401

4.  Familial empirical risks for inflammatory bowel disease: differences between Jews and non-Jews.

Authors:  H Yang; C McElree; M P Roth; F Shanahan; S R Targan; J I Rotter
Journal:  Gut       Date:  1993-04       Impact factor: 23.059

Review 5.  The complexity and challenges of genetic counseling and testing for inflammatory bowel disease.

Authors:  Shelly A Cummings; David T Rubin
Journal:  J Genet Couns       Date:  2006-12       Impact factor: 2.537

Review 6.  Breastfeeding and genetic factors in the etiology of inflammatory bowel disease in children.

Authors:  Theresa A Mikhailov; Sylvia E Furner
Journal:  World J Gastroenterol       Date:  2009-01-21       Impact factor: 5.742

7.  Investigation of inheritance of chronic inflammatory bowel diseases by complex segregation analysis.

Authors:  M Orholm; L Iselius; T I Sørensen; P Munkholm; E Langholz; V Binder
Journal:  BMJ       Date:  1993-01-02

8.  Association of Clinical Features with Human Leukocyte Antigen in Japanese Patients with Ulcerative Colitis.

Authors:  Taku Iwamoto; Kazuo Yashima; Keiko Morio; Naoki Ueda; Yuichiro Ikebuchi; Koichiro Kawaguchi; Kenichi Harada; Hajime Isomoto
Journal:  Yonago Acta Med       Date:  2018-03-28       Impact factor: 1.641
  8 in total

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