| Literature DB >> 25908505 |
Xiao-Jie Lu1, Xiaolong Qi2, Dong-Hui Zheng3, Li-Juan Ji4.
Abstract
CRISPR-Cas9 is an RNA-guided site-specific DNA editing tool which, together with its reprogrammed versions such as nickase Cas9 and dead Cas9, enables quick modeling of desired combinations of cancer-associated genomic and/or epigenetic aberrations simultaneously or sequentially, thus facilitating massive functional interrogations and therapy testing.Entities:
Mesh：
Year: 2015 PMID： 25908505 DOI： 10.1016/j.tibtech.2015.03.007
Source DB: PubMed Journal: Trends Biotechnol ISSN： 0167-7799 Impact factor: 19.536