Y H Lee1, S-C Bae2, S J Choi3, J D Ji3, G G Song3. 1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea lyhcgh@korea.ac.kr. 2. The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, Korea. 3. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Abstract
OBJECTIVE: The aim of this study was to determine whether the functional CD40 rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). METHODS: A series of meta-analyses were conducted to test for association between the CD40 rs4810485 G/T polymorphism and RA or SLE. RESULTS: A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40 rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846-0.936, p = 5.5 × 10(-7)). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848-0.901, p = 3.0 × 10(-9)). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641-0.832, p = 1.4 × 10(-6)). CONCLUSIONS: Our meta-analyses confirm that the CD40 rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
OBJECTIVE: The aim of this study was to determine whether the functional CD40rs4810485 G/T polymorphism is associated with susceptibility to rheumatoid arthritis (RA) or with susceptibility to systemic lupus erythematosus (SLE). METHODS: A series of meta-analyses were conducted to test for association between the CD40rs4810485 G/T polymorphism and RA or SLE. RESULTS: A total of 21 comparisons involving 15,095 patients and 27,050 controls for RA, and 1353 patients and 2342 controls for SLE were considered. Meta-analysis showed a significant association between the CD40rs4810485 T allele and RA in all subjects (odds ratio (OR) 0.890, 95% confidence interval (CI) 0.846-0.936, p = 5.5 × 10(-7)). After stratification by ethnicity, the CD40 T allele was found to be significantly associated with RA in Europeans (OR 0.879, 95% CI 0.848-0.901, p = 3.0 × 10(-9)). A similar pattern of association was observed between the CD40 T allele and RA when the analysis was performed using the recessive, dominant, and additive models. Meta-analysis also showed a significant association between the CD40 polymorphism and SLE in Europeans (OR for the T allele 0.715, 95% CI 0.641-0.832, p = 1.4 × 10(-6)). CONCLUSIONS: Our meta-analyses confirm that the CD40rs4810485 G/T polymorphism is associated with susceptibility to RA and SLE in Europeans.
Authors: Sudha Visvanathan; Stefan Daniluk; Rafał Ptaszyński; Ulf Müller-Ladner; Meera Ramanujam; Bernd Rosenstock; Anastasia G Eleftheraki; Richard Vinisko; Alena Petříková; Herbert Kellner; Eva Dokoupilova; Brygida Kwiatkowska; Rieke Alten; Christian Schwabe; Patrick Baum; David Joseph; Jay S Fine; Steven J Padula; Jürgen Steffgen Journal: Ann Rheum Dis Date: 2019-03-22 Impact factor: 19.103