| Literature DB >> 25905457 |
Donghee Son1,2, Jongha Lee1,2, Dong Jun Lee1,2, Roozbeh Ghaffari3, Sumin Yun4, Seok Joo Kim1,2, Ji Eun Lee1,2, Hye Rim Cho1,5, Soonho Yoon5, Shixuan Yang6, Seunghyun Lee5, Shutao Qiao6, Daishun Ling7, Sanghun Shin1,2, Jun-Kyul Song1,2, Jaemin Kim1,2, Taeho Kim1,2, Hakyong Lee1,2, Jonghoon Kim1,2, Min Soh1,2, Nohyun Lee8, Cheol Seong Hwang9, Sangwook Nam4, Nanshu Lu6, Taeghwan Hyeon1,2, Seung Hong Choi1,5, Dae-Hyeong Kim1,2.
Abstract
Implantable endovascular devices such as bare metal, drug eluting, and bioresorbable stents have transformed interventional care by providing continuous structural and mechanical support to many peripheral, neural, and coronary arteries affected by blockage. Although effective in achieving immediate restoration of blood flow, the long-term re-endothelialization and inflammation induced by mechanical stents are difficult to diagnose or treat. Here we present nanomaterial designs and integration strategies for the bioresorbable electronic stent with drug-infused functionalized nanoparticles to enable flow sensing, temperature monitoring, data storage, wireless power/data transmission, inflammation suppression, localized drug delivery, and hyperthermia therapy. In vivo and ex vivo animal experiments as well as in vitro cell studies demonstrate the previously unrecognized potential for bioresorbable electronic implants coupled with bioinert therapeutic nanoparticles in the endovascular system.Entities:
Keywords: bioresorbable; flexible electronics; nanomedicine; stent; transient electronics
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Year: 2015 PMID： 25905457 DOI： 10.1021/acsnano.5b00651
Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881